Clinical periodontal status and inflammatory cytokines in primary Sjögren syndrome and rheumatoid arthritis
| Autor: | Ayse Nalbantsoy, Gonca Karabulut, Yasemin Kabasakal, Özgün Özçaka, Esin Alpöz |
|---|---|
| Přispěvatelé: | Ege Üniversitesi |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Bleeding on probing Gastroenterology Proinflammatory cytokine Arthritis Rheumatoid 03 medical and health sciences Gingivitis 0302 clinical medicine Internal medicine medicine Humans Interferon gamma Primary Sjögren Syndrome 030203 arthritis & rheumatology business.industry Tumor Necrosis Factor-alpha Case-control study 030206 dentistry Gingival Crevicular Fluid medicine.disease stomatognathic diseases Sjogren's Syndrome Rheumatoid arthritis Case-Control Studies Periodontics Cytokines Tumor necrosis factor alpha medicine.symptom business medicine.drug |
| Zdroj: | Journal of periodontology. 89(8) |
| ISSN: | 1943-3670 |
| Popis: | BACKGROUND The aim of the present study is to compare the clinical periodontal findings as well as gingival crevicular fluid (GCF) and plasma levels of tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), interferon gamma (IFN-γ) and caspase-1 in primary Sjogren syndrome (pSS) and rheumatoid arthritis (RA) subjects. METHODS In the present case control study plasma and GCF samples were collected, full-mouth recordings comprising plaque index (PI), bleeding on probing (BOP) and probing depth (PD) were performed in 44 subjects with pSS, 39 subjects with RA and 30 systemically healthy subjects. Plasma and GCF TNF-α, IL-1β, IFN-gamma and caspase-1 levels were determined by enzyme-linked immunosorbent assay. RESULTS There were no differences in GCF and plasma levels of IFN-γ and TNF-α in all the study groups (p > 0.05). GCF levels of IL-1β were higher in pSS group than healthy group (p = 0.035). Caspase-1 GCF levels were significantly higher in pSS group than RA group (p = 0.032). Highest plasma IL-1β levels were detected in pSS compared to RA and healthy groups (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text