IgM-PRODUCING TUMORS IN THE BALB/c MOUSE

Autor:	Luciana Forni, Jan Andersson, David I. Stott, Ronald Citronbaum, Joel N. Buxbaum, Benvenuto Pernis, Steven D. Douglas, Fritz Melchers
Jazyk:	angličtina
Rok vydání:	1974
Předmět:	medicine.diagnostic_test BALB/c Mouse Errata B cell maturation medicine.medical_treatment Immunology Metabolism Biology medicine.disease Immunofluorescence Molecular biology law.invention law medicine Immunology and Allergy Neoplasm Secretion Electron microscope Erratum Adjuvant
Zdroj:	The Journal of Experimental Medicine
ISSN:	1540-9538 0022-1007
Popis:	Five adjuvant induced BALB/c tumors producing IgM—McPc 1748, W 3469, TEPC 183, McPc 774, and Y 5781—were characterized morphologically by electron microscopy, analysis of the distribution of surface-bound and intracytoplasmic IgM using immunofluorescence, and by biochemical study of IgM synthesis, turnover, and secretion. The cells of different tumors appear to represent different stages in B-cell maturation when compared to normal, lipopolysaccharide-stimulated B cells. Thus, McPc 1748 tumor cells resemble 10–25-h stimulated normal B cells, 3469 cells resemble 20–35-h stimulated B cells, TEPC 183 cells resemble 45–65-h stimulated B cells, Y 5781 cells resemble 80–110-h stimulated B cells, and McPc 774 cells resemble 100–130-h stimulated B cells.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d1ecd37ed787acf16d1b46e69480e3 http://europepmc.org/articles/PMC2139754 Zobrazit plný text záznamu