Autor: |
Wei Li, Qin Wang, Jason Shaoyun Xiang, Jeremy I. Levin, Leif M. Laakso, Xuemei Du, Thomas S. Rush, Jennifer R. Thomason, Manus Ipek, Tam Steve Yik-Kai, Yonghan Hu, Jerauld S. Skotnicki, Jean Schmid, Martin J. DiGrandi, Jianchang Li |
Rok vydání: |
2005 |
Předmět: |
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Zdroj: |
Bioorganic & Medicinal Chemistry. 13:6629-6644 |
ISSN: |
0968-0896 |
Popis: |
Modification of alpha-biphenylsulfonamidocarboxylic acids led to potent and selective MMP-13 inhibitors. Compound 16 showed 100% oral bioavailability in rats and demonstrated50% inhibition of bovine cartilage degradation at 10 ng/mL. |
Databáze: |
OpenAIRE |
Externí odkaz: |
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