Allele frequencies of dopamine D4 receptor gene (DRD4) and Catechol-O-methyltransferase (COMT) Val158Met polymorphism are associated with methylphenidate response in adolescents with attention deficit/hyperactivity disorder: a case control preliminary study
| Autor: | Süha Miral, Sebnem Yildirimcan Kadicesme, Sevay Alşen Güney, Sefa Kizildag, Gonca Özyurt, Handan Özek Erkuran, Aynur Pekcanlar Akay, Çiğdem Eresen Yazıcıoğlu, Burak Baykara, Neslihan İnal Emiroğlu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
050103 clinical psychology
medicine.medical_specialty methylphenidate Neurosciences. Biological psychiatry. Neuropsychiatry 03 medical and health sciences 0302 clinical medicine Polymorphism (computer science) Dopamine Internal medicine mental disorders Medicine Attention deficit hyperactivity disorder 0501 psychology and cognitive sciences Pharmacology (medical) adolescents Allele Receptor Allele frequency Catechol-O-methyl transferase business.industry Methylphenidate catechol-O-methyltransferase gene (COMT) 05 social sciences Attention deficit/hyperactivity disorder medicine.disease dopamine D4 receptor gene (DRD4) Psychiatry and Mental health clinical global impression (CGI) business 030217 neurology & neurosurgery RC321-571 medicine.drug |
| Zdroj: | Psychiatry and Clinical Psychopharmacology, Vol 28, Iss 2, Pp 177-184 (2018) |
| Popis: | OBJECTIVES: In this study, it was aimed to analyse the relationship between clinical improvement in adolescents with attention deficit/hyperactivity disorder (ADHD) and the presence of allele frequencies of dopamine D4 receptor (DRD4), and Val158Met polymorphism of catechol-O-methyltransferase (COMT) genes. METHODS: Thirty-four adolescents (age range, 13–18 years) with ADHD participated in this study. Thirty-two patients were males and two were females. Du Paul ADHD Rating Scale-Clinician version (ARS) and Clinical Global Impression-severity of impairment (CGI-S) were used for the evaluation of symptom severity. Fifty healthy age-matched adolescents were recruited as controls. RESULTS: When the groups with (n = 9) and without (n = 25) 7-repeat alleles for DRD4 were considered, there was a statistically significant decrease of DuPaul ARS total and hyperactivity scores in those treated with OROS-methylphenidate. When the Val/Met allele-positive group for COMT gene (n = 17) was compared with the Val/Val allele-positive group (n = 13) and Met/Met allele-positive group (n = 4), there was a statistically significant decrease of ARS total scores, ARS attention scores, and CGI scores in adolescents with ADHD treated with OROS-MPH. CONCLUSIONS: Specific data from further studies with a larger sample sizes would provide more insights to replicate the current findings. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|