An Electrode Array for Limiting Blood Loss During Liver Resection: Optimization via Mathematical Modeling
| Autor: | David M. Mahvi, David J. Schutt, R.M Strigel, John G. Webster, Dieter Haemmerich |
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| Rok vydání: | 2010 |
| Předmět: |
medicine.medical_specialty
business.industry Biomedical Engineering Medicine (miscellaneous) Bioengineering Limiting Metastatic liver cancer Article Surgery Resection Cross section (geometry) 03 medical and health sciences 0302 clinical medicine Increased risk Blood loss 030220 oncology & carcinogenesis Electrode medicine Electrode array 030211 gastroenterology & hepatology business Biomedical engineering |
| Zdroj: | The Open Biomedical Engineering Journal |
| ISSN: | 1874-1207 |
| Popis: | Liver resection is the current standard treatment for patients with both primary and metastatic liver cancer. The principal causes of morbidity and mortality after liver resection are related to blood loss (typically between 0.5 and 1 L), especially in cases where transfusion is required. Blood transfusions have been correlated with decreased long-term survival, increased risk of perioperative mortality and complications. The goal of this study was to evaluate different designs of a radiofrequency (RF) electrode array for use during liver resection. The purpose of this electrode array is to coagulate a slice of tissue including large vessels before resecting along that plane, thereby significantly reducing blood loss. Finite Element Method models were created to evaluate monopolar and bipolar power application, needle and blade shaped electrodes, as well as different electrode distances. Electric current density, temperature distribution, and coagulation zone sizes were measured. The best performance was achieved with a design of blade shaped electrodes (5 × 0.1 mm cross section) spaced 1.5 cm apart. The electrodes have power applied in bipolar mode to two adjacent electrodes, then switched sequentially in short intervals between electrode pairs to rapidly heat the tissue slice. This device produces a ~1.5 cm wide coagulation zone, with temperatures over 97 ºC throughout the tissue slice within 3 min, and may facilitate coagulation of large vessels. |
| Databáze: | OpenAIRE |
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