High-risk genotypes HLA-DR3-DQ2/DR3-DQ2 and DR3-DQ2/DR4-DQ8 in co-occurrence of type 1 diabetes and celiac disease

Autor:	Nina Bratanic, Sabina Kunilo Jamnik, Andrijana Mendez, Natasa Bratina, Blanka Vidan-Jeras, Darja Smigoc Schweiger, Jernej Brecelj, Tadej Battelino
Rok vydání:	2016
Předmět:	0301 basic medicine Male Risk endocrine system endocrine system diseases Genotype Immunology HLA-DR3 Autoimmunity Human leukocyte antigen Biology 03 medical and health sciences 0302 clinical medicine immune system diseases HLA-DQ Antigens medicine Genetic predisposition Immunology and Allergy Humans Genetic Predisposition to Disease Allele Alleles Genetic Association Studies Type 1 diabetes Histocompatibility Testing nutritional and metabolic diseases Odds ratio HLA-DR Antigens medicine.disease Exact test Celiac Disease 030104 developmental biology Diabetes Mellitus Type 1 Haplotypes Female 030215 immunology
Zdroj:	Autoimmunity. 49(4)
ISSN:	1607-842X
Popis:	Shared susceptibility alleles in the HLA region contribute to the co-existence of type 1 diabetes (T1D) and celiac disease (CD). The aim of our study was to identify HLA genotype variations that influence co-occurrence of T1D and CD (T1D + CD) and the order of their onset. Totally 244 patients, 67 with T1D, 68 with CD and 69 with T1D + CD, (split into "T1D first" and "CD first"), were analyzed. Control group consisted of 130 healthy unrelated individuals. Two-tailed Fisher's exact test was used for statistical analysis. The genetic background of Slovenian CD patients resembled more northern than southern European populations with DR3-DQ2/DR3-DQ2 (odds ratio [OR] = 19.68) conferring the highest risk. The T1D + CD was associated with DR3-DQ2/DR3-DQ2 (OR = 45.53) and even more with DR3-DQ2/DR4-DQ8 (OR = 93.76). DR3-DQ2/DR7-DQ2 played a neutral role in susceptibility for T1D + CD. The order of the onset of T1D or CD in patients with co-occurring diseases was not influenced by HLA risk genotype profile. DR3-DQ2/DR3-DQ2 was associated with an increased risk for developing CD in patients with T1D, whereas patients with CD carrying DR3-DQ2/DR4-DQ8 were at higher risk for developing T1D. In addition to other genetic factors including HLA class I alleles present on DR3-DQ2 extended haplotype, the second extended haplotype may moderate the risk for T1D + CD conferred by DR3-DQ2. Our results suggested that individuals carrying high-risk genotypes DR3-DQ2/DR3-DQ2 or DR3-DQ2/DR4-DQ8 would more likely develop both T1D and CD than either disease alone.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22cb86486c5b186540011b10a5ce09d9 https://pubmed.ncbi.nlm.nih.gov/27138053 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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