The Role of Metformin in Ovarian Cancer: Does Metformin Increase Survival in Ovarian Neoplasm?
| Autor: | Ghid Kanaan, Maimuna F Ahmed, Jihan A Mostafa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Oncology
epithelial ovarian cancer medicine.medical_specialty endocrine system diseases English language 030204 cardiovascular system & hematology ovarian neoplasm law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial law Internal medicine medicine Overall survival Neoplasm dimethylbiguanides business.industry Mortality rate General Engineering ovary cancer Evidence-based medicine medicine.disease female genital neoplasm Metformin biguanides Obstetrics/Gynecology Ovarian cancer business metformin 030217 neurology & neurosurgery Family/General Practice medicine.drug |
| Zdroj: | Cureus |
| ISSN: | 2168-8184 |
| Popis: | The role of metformin in ovarian cancer (OC) remains a topic of research and open discussion. Because OC has a high mortality rate for various reasons, finding a solution is vital. Although metformin has demonstrated a high level of evidence in preventing and increasing survival in other cancers, its role in OC is still not proven. This review highlights the function of metformin as an antineoplastic agent in OC and its effect on overall survival, progress-free survival, and recurrence-free survival. We conducted a literature search in the PubMed database using the medical subject heading keywords, ovarian neoplasm and metformin. The search yielded 94 articles, of which 86 remained after including only English language articles. Finally, 50 articles published between 1997 and 2020 were reviewed. We recommend more randomized controlled trials in the future to determine the safety and efficacy of metformin in OC. |
| Databáze: | OpenAIRE |
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