Evaluation of pheniramine maleate and zofenopril in reducing renal damage induced by unilateral ureter obstruction. An experimental study
| Autor: | Tunç Ozan, Erdal Yilmaz, Ercan Yuvanc, Mahi Balci, Ertan Batislam, Devrim Tuglu, Ucler Kisa |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
kidney
medicine.medical_specialty Experimental Research Necrosis Pheniramine Maleate Urology 030204 cardiovascular system & hematology partial unilateral ureter obstruction 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ureter hydronephrosis total oxidant status Medicine zofenopril 030212 general & internal medicine pheniramine maleate Hydronephrosis Kidney biology business.industry Paraoxonase General Medicine medicine.disease paraoxonase Ureter Obstruction Zofenopril medicine.anatomical_structure chemistry oxidative stress index biology.protein total antioxidant capacity medicine.symptom business |
| Zdroj: | Archives of Medical Science : AMS |
| ISSN: | 1896-9151 1734-1922 |
| DOI: | 10.5114/aoms.2019.88320 |
| Popis: | IntroductionObstruction of the ureter may occur due to congenital, iatrogenic or other reasons. This can cause hydronephrosis in the early stage and can lead to cellular inflammation, necrosis and atrophy in the kidney tissue. The aim of this paper is to evaluate the protective effect of pheniramine maleate (PM) and zofenopril on renal damage caused by hydronephrosis due to unilateral partial ureter obstruction.Material and methodsTwenty-four female Sprague Dawley rats were divided into 4 groups. Group 1: sham group, group 2: partial unilateral ureteral obstruction (PUUO) group, group 3: PUUO + PM group, group 4: PUUO + zofenopril group. Paraoxonase (PON), total antioxidant status (TAS) and total oxidant status (TOS) of tissue and blood samples were measured and calculated. Tissue samples were evaluated histopathologically.ResultsAn increase in tissue TAS and a decrease in tissue TOS and OSI levels were detected in groups 3 and 4 compared to group 2 (both: p < 0.01). Tissue PON levels showed an increase in groups 3 and 4 compared to groups 1 and 2 (both: p < 0.01). Histopathological evaluation showed a decrease in interstitial inflammation and congestion in groups 3 and 4 compared to the control group (p < 0.001). The decrease was observed to be more significant in group 4 compared to group 3 (p < 0.01).ConclusionIn our experimental study, we observed that PM and zofenopril reduce the oxidation and tissue damage caused by unilateral partial obstruction. |
| Databáze: | OpenAIRE |
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