Dengue Virus Immunity Increases Zika Virus-Induced Damage during Pregnancy
| Autor: | Justin J. Frere, Adam Jacobs, Richard Cadagan, Jean K. Lim, Julia A. Brown, Gregory A. Foster, Florian Krammer, Silviana Lee, Gursewak Singh, Kevin W. Hoffman, James Duehr, Anupa Chokola, David E. Krysztof, Susan L. Stramer, Joshua A. Acklin, Adolfo García-Sastre |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
viruses Immunology Cross Reactions Dengue virus Antibodies Viral medicine.disease_cause Article Zika virus Mice 03 medical and health sciences 0302 clinical medicine Pregnancy Cell Line Tumor Chlorocebus aethiops Blocking antibody medicine Animals Humans Immunology and Allergy Antibody-dependent enhancement Vero Cells Fetus biology Zika Virus Infection Immunity Antibodies Monoclonal Zika Virus Dengue Virus biology.organism_classification medicine.disease Antibodies Neutralizing Antibody-Dependent Enhancement Virology Flavivirus 030104 developmental biology Infectious Diseases Viral replication 030220 oncology & carcinogenesis Female K562 Cells |
| Zdroj: | Immunity. 50:751-762.e5 |
| ISSN: | 1074-7613 |
| DOI: | 10.1016/j.immuni.2019.01.005 |
| Popis: | Zika virus (ZIKV) has recently been associated with birth defects and pregnancy loss after maternal infection. Because dengue virus (DENV) and ZIKV co-circulate, understanding the role of antibody-dependent enhancement in the context of pregnancy is critical. Here, we showed that the presence of DENV-specific antibodies in ZIKV-infected pregnant mice significantly increased placental damage, fetal growth restriction, and fetal resorption. This was associated with enhanced viral replication in the placenta that coincided with an increased frequency of infected trophoblasts. ZIKV-infected human placental tissues also showed increased replication in the presence of DENV antibodies, which was reversed by FcγR blocking antibodies. Furthermore, ZIKV-mediated fetal pathogenesis was enhanced in mice in the presence of a DENV-reactive monoclonal antibody, but not in the presence of the LALA variant, indicating a dependence on FcγR engagement. Our data suggest a possible mechanism for the recent increase in severe pregnancy outcomes after ZIKV infection in DENV-endemic areas. |
| Databáze: | OpenAIRE |
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