Increased Endothelial Expression of Intercellular Adhesion Molecule-1 in Symptomatic Versus Asymptomatic Human Carotid Atherosclerotic Plaque
| Autor: | LaRoy Penix, Ronald Hargraves, Richard M. McCarron, Anna-Leena Sirén, John M. Hallenbeck, Karen D. Pettigrew, Suman Sood, Thomas J. DeGraba |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Carotid Artery Diseases Male Pathology medicine.medical_specialty Endothelium Arteriosclerosis medicine.medical_treatment Endarterectomy Carotid endarterectomy Asymptomatic Pathogenesis Reference Values White blood cell medicine Humans Postoperative Period Aged Aged 80 and over Advanced and Specialized Nursing Analysis of Variance business.industry Vascular disease Middle Aged Intercellular Adhesion Molecule-1 medicine.disease Thrombosis Stenosis medicine.anatomical_structure Solubility Female Endothelium Vascular Neurology (clinical) medicine.symptom Cardiology and Cardiovascular Medicine business |
| Zdroj: | Stroke. 29:1405-1410 |
| ISSN: | 1524-4628 0039-2499 |
| DOI: | 10.1161/01.str.29.7.1405 |
| Popis: | Background and Purpose —The mechanisms that cause carotid atherosclerotic plaque to become symptomatic remain unclear. Evidence suggests that mediators of inflammation are not only instrumental in the formation of plaque but may also be involved in the rapid progression of atheromatous lesions leading to plaque fissuring, endothelial injury, and intraluminal thrombosis. Our goal is to determine whether intercellular adhesion molecule-1 (ICAM-1), a known component of the inflammatory pathway, is preferentially expressed on symptomatic versus asymptomatic carotid plaques. Methods —Carotid plaques from symptomatic (n=25) and asymptomatic (n=17) patients undergoing carotid endarterectomy with lesions involving >60% stenosis were snap-frozen at the time of surgery. Immunofluorescence studies were performed to measure the percentage of luminal endothelial surface that expressed ICAM-1. The relationships of stroke risk factors, white blood cell count, percent stenosis, and soluble ICAM-1 (sICAM-1) plasma levels to endothelial ICAM-1 expression were investigated. Results —An increased expression of ICAM-1 was found in the high-grade regions of symptomatic (29.5%±2.4%, mean±SEM) versus asymptomatic (15.7%±2.7%, mean±SEM) plaques ( P =0.002) and in the high-grade versus the low-grade region of symptomatic plaques (29.5±2.4, mean±SEM, versus 8.9±1.6; P Conclusions —An elevation in ICAM-1 expression in symptomatic versus asymptomatic plaque suggests that mediators of inflammation are involved in the conversion of carotid plaque to a symptomatic state. The data also suggest a differential expression of ICAM-1, with a greater expression found in the high-grade region than in the low-grade region of the plaque specimen. |
| Databáze: | OpenAIRE |
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