Studies on hypolipidemic agents. IV. 3-(4-(Phenylthio)benzoyl)propionic acid derivatives
| Autor: | Yumiko Asami, Kazuya Kameo, Kunio Ogawa, Kazuyuki Tomisawa, Shiuji Saito, Tohru Matsunaga, Kaoru Sota |
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| Rok vydání: | 1989 |
| Předmět: |
Male
Clofibrate Chemical Phenomena Propionic acid derivatives Biological activity General Chemistry General Medicine Benzoates Rats Acylation Chemistry chemistry.chemical_compound chemistry Drug Discovery Hypolipidemic Agents medicine Animals Structure–activity relationship Organic chemistry Sulfhydryl Compounds Benzene Friedel–Crafts reaction medicine.drug |
| Zdroj: | Chemical and Pharmaceutical Bulletin. 37:1260-1267 |
| ISSN: | 1347-5223 0009-2363 |
| DOI: | 10.1248/cpb.37.1260 |
| Popis: | 2-Acetylthio-3-benzoylpropionic acid derivatives having two benzene rings or condensed-ring moieties were prepared, and tested for hypolipidemic activity in normal rats. Some of these compounds were active. 2-Acetylthio-3-[4-(phenylthio)benzoyl]propionic acid (10) and its derivatives seemed to have the most potent hypocholesterolemic activities. Compound 10 showed strong activity, especially in cholesterol-fed rats. |
| Databáze: | OpenAIRE |
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