Association between G1733A (rs6152) polymorphism in androgen receptor gene and recurrent spontaneous abortions in Mexican population
| Autor: | Thiago Donizete Da Silva-José, Angela Porras-Dorantes, Aniel Jessica Leticia Brambila-Tapia, José Elías García-Ortiz, Jesús Alejandro Juárez-Osuna, Alma Benita Lazcano-Castellanos |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Adult medicine.medical_specialty Abortion Habitual Adolescent Population Single-nucleotide polymorphism Abortion Biology Polymorphism Single Nucleotide 03 medical and health sciences Young Adult 0302 clinical medicine Polymorphism (computer science) Pregnancy Genotype Genetics medicine SNP Humans Genetic Predisposition to Disease education Author Correction Allele frequency Mexico Genetics (clinical) Gynecology education.field_of_study 030219 obstetrics & reproductive medicine Obstetrics and Gynecology General Medicine 030104 developmental biology Reproductive Medicine Receptors Androgen Case-Control Studies Female Restriction fragment length polymorphism Developmental Biology |
| Zdroj: | Journal of assisted reproduction and genetics. 34(10) |
| ISSN: | 1573-7330 |
| Popis: | Recurrent spontaneous abortion (RSA) is a multifactorial condition that occurs with a frequency of 0.2-5% in women of reproductive age. Among genetic factors, the single nucleotide polymorphism (SNP) G1733A in the androgen receptor (AR) gene has been associated with its presence in Greek and Iranian populations. Therefore, the aim of this study is to determine its possible association with RSA in this population.A total of 156 Mexican RSA (with at least 2 consecutive abortions) unrelated patients and 152 unrelated healthy women were included, the presence of karyotype anomalies in the parents as well as uterine anomalies as well as antiphospholipid antibodies was excluded in patients; while all the controls presented at least two healthy pregnancies and no abortion. In all the included women, the presence of the SNP G1733A was determined by restriction fragment length polymorphism (RFLP) technique.No significant differences were observed in age between groups. The genotype GG, GA, and AA had a frequency of 0.70, 0.27, and 0.03 in patients and of 0.89, 0.10, and 0.01 in controls [corrected] (p 0.001); while the A allele frequency was of 0.06 and 0.16 in controls and patients, respectively (p 0.0001). The difference in allele frequency increased 10-15% when patients with primary RSA (with no live births) and with at least three abortions were included.The SNP G1733A of the AR gene is significantly associated with RSA in Mexican patients. These results coincide with previous reports in other populations. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink