A role for serotonin in lipopolysaccharide-induced anorexia in rats
| Autor: | Brian J Hrupka, Wolfgang Langhans |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Lipopolysaccharides
Male Agonist Serotonin medicine.medical_specialty Metergoline medicine.drug_class 5 7-Dihydroxytryptamine Clinical Biochemistry Anorexia Toxicology Cisterna magna Biochemistry Rats Sprague-Dawley Eating Behavioral Neuroscience chemistry.chemical_compound Serotonin Agents Internal medicine Cisterna Magna medicine Animals Biological Psychiatry Pharmacology 8-Hydroxy-2-(di-n-propylamino)tetralin Dose-Response Relationship Drug Chemistry 8-OH-DPAT Antagonist Rats Serotonin Receptor Agonists Endocrinology Anorectic lipids (amino acids peptides and proteins) Serotonin Antagonists medicine.symptom |
| Zdroj: | Pharmacology Biochemistry and Behavior. 68:355-362 |
| ISSN: | 0091-3057 |
| Popis: | Rats consistently reduce their food intake following injection of bacterial lipopolysaccharides (LPS). Because LPS increases CNS serotonin (5-HT) turnover, and because increases in CNS 5-HT turnover are associated with a decrease in food intake, we conducted a series of studies to examine 5-HT's potential role in LPS-induced anorexia. Chronic CNS 5-HT depletion by cisterna magna (CM) administration of 5,7-dihydroxytryptamine (5,7-DHT) failed to attenuate LPS-induced (100 microg/kg, ip) anorexia. In subsequent experiments, LPS was injected at lights out (hour 0) and [8-hydroxy-2-(di-n-propylamino)tetraline (8-OH-DPAT)] or N-CBZ-[(8beta)-1,6-dimethylergolin-8-yl]methylamine (metergoline) was injected at hour 5 - the time when LPS-treated rats become anorectic. Food intake was measured during the subsequent 2 h. In LPS-treated rats, 8-OH-DPAT (62.5, 125, or 250 microg/kg, sc) injection increased food intake. In a 2 x 2 factorial arrangement of LPS and 8-OH-DPAT, 125 microg/kg 8-OH-DPAT increased food intake significantly more in LPS-treated rats than in non-LPS-treated rats (significant LPS x 8-OH-DPAT interaction). In LPS-treated rats, 1 and 5 mg/kg metergoline significantly enhanced food intake. However, in a 2 x 2 arrangement of LPS and metergoline, 1 mg/kg metergoline failed to increase food intake in LPS and non-LPS-treated rats in two separate trials. The ability of the 5-HT(1A) receptor agonist 8-OH-DPAT to attenuate LPS-induced anorexia in rats supports a role of 5-HT in LPS-induced anorexia. |
| Databáze: | OpenAIRE |
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