The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells
| Autor: | Marjoleine L. Op den Brouw, Andrea M. Woltman, Harry L.A. Janssen, Rekha S. Binda, Teunis B.H. Geijtenbeek |
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| Přispěvatelé: | Gastroenterology & Hepatology, Center of Experimental and Molecular Medicine, Molecular cell biology and Immunology, CCA - Immuno-pathogenesis |
| Rok vydání: | 2009 |
| Předmět: |
HBsAg
Hepatitis B virus Receptors Cell Surface Biology Myeloid dendritic cells medicine.disease_cause Flow cytometry Antigen SDG 3 - Good Health and Well-being Virology medicine HBV Humans Lectins C-Type Receptor Mannan-binding lectin Hepatitis B Surface Antigens medicine.diagnostic_test virus diseases Dendritic Cells Hepatitis B medicine.disease digestive system diseases C-type lectin Blood Mannose-Binding Lectins Liver CD206 Mannose receptor HBV surface antigen Immunology Protein Binding |
| Zdroj: | den Brouw, M L O, Binda, R S, Geijtenbeek, T B H, Janssen, H-G & Woltman, A M 2009, ' The mannose receptor acts as hepatitis B virus surface antigen receptor mediating interaction with intrahepatic dendritic cells ', Virology, vol. 393, no. 1, pp. 84-90 . https://doi.org/10.1016/j.virol.2009.07.015 Virology, 393(1), 84-90. Academic Press Virology, 393(1), 84-90. Academic Press Inc. |
| ISSN: | 0042-6822 |
| DOI: | 10.1016/j.virol.2009.07.015 |
| Popis: | Dendritic cells (DC) play a key role in anti-viral immunity. Direct interactions between DC and hepatitis B virus (HBV) may explain the impaired DC function and the ineffective anti-viral response of chronic HBV patients resulting in HBV persistence, Here, the interaction between HBV surface antigens (HBsAg) and DC and the receptor involved were examined by flow cytometry in blood and liver tissue of HBV patients. The in vitro data showed that the mannose receptor (MR) is involved in HBsAg recognition and uptake by DC. The presence of HBsAg-positive DC was demonstrated sporadically in blood, but frequently in the liver of HBV patients. Interestingly, a positive correlation was found between HBsAg positivity and MR expression level in both liver- and blood-derived DC. These data suggest that in HBV infected patients, MR-mediated interaction between HBsAg and DC and subsequent impairment of DC predominantly occurs at the main site of infection, the liver. (C) 2009 Elsevier Inc. All rights reserved |
| Databáze: | OpenAIRE |
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