Inhospital exercise benefits in childhood cancer: A prospective cohort study
Autor: | Javier S. Morales, Alejandro Santos-Lozano, Marta González Vicent, David Fernández-Moreno, Alejandro Lucia, Marta Perez-Somarriba, Luis Madero, Carmen Fiuza-Luces, Cecilia Rincón-Castanedo, Elena Santana-Sosa, Alvaro Lassaletta, Pedro L. Valenzuela, Antonio Baño-Rodrigo |
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Rok vydání: | 2019 |
Předmět: |
Male
medicine.medical_specialty Adolescent Physical Therapy Sports Therapy and Rehabilitation 030204 cardiovascular system & hematology Ventricular Function Left 03 medical and health sciences 0302 clinical medicine Recurrence Interquartile range Neoplasms Internal medicine Clinical endpoint Humans Medicine Orthopedics and Sports Medicine Prospective Studies Child Adverse effect Prospective cohort study Ejection fraction business.industry Pediatría Cancer 030229 sport sciences Cáncer Deporte Anthropometry medicine.disease Ejercicio físico Exercise Therapy Hospitalization Child Preschool Cohort Female Neoplasm Recurrence Local business |
Zdroj: | Scandinavian Journal of Medicine & Science in Sports. 30:126-134 |
ISSN: | 1600-0838 0905-7188 |
Popis: | Childhood cancer patients are at risk of developing important adverse effects, mortality and disease relapse after treatments, which has a substantial economic impact on healthcare systems. The objective of this study was to determine the effects of supervised inhospital exercise on clinical endpoints during childhood cancer treatment. 169 children with a new diagnosis of cancer were divided into an exercise intervention (n = 68, 11 ± 4 years) or a control group (n = 101, 11 ± 3 years). The cohort was followed up from the start of treatment for up to five years. Supervised inhospital exercise intervention was performed during the neoadjuvant (for solid tumors) or intensive chemotherapy treatment period (for leukemias). The median duration of the intervention was 22 (interquartile range, 14‐28) weeks. We assessed survival, risk of disease relapse or metastasis, and days of hospitalization (primary outcomes), and cardiovascular function, anthropometry and blood variables (secondary outcomes). No exercise‐related adverse events were noted. The exercise group had significantly less days of hospitalization than the control group (P = .031), resulting in a lower (~−17%) mean total economic cost of hospitalization in the former. Moreover, echocardiography‐determined left ventricular function (ejection fraction and fractional shortening) was significantly impaired in the control group after treatment compared with baseline, whereas it was maintained in the exercise group (P = .024 and .021 for the between‐group differences, respectively). In conclusion, supervised inhospital exercise intervention is safe and plays a cardioprotective role, at least in the short term, in children with cancer, also reducing hospitalization time, and therefore alleviating the economic burden. Sin financiación 4.221 JCR (2020) Q1, 18/88 Sport Sciences 1.575 SJR (2020) Q1, 27/288 Orthopedics and Sports Medicine No data IDR 2019 UEM |
Databáze: | OpenAIRE |
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