Drosophila melanogasteras a model system to study long-chain fatty acid amide metabolism
| Autor: | Kristen A. Jeffries, Daniel R. Dempsey, David J. Merkler, Anita L. Behari, Ryan L. Anderson |
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| Rok vydání: | 2014 |
| Předmět: |
Coenzyme A
Biophysics Palmitic Acids Biochemistry Article Palmitic acid chemistry.chemical_compound Model system Structural Biology Fatty acid amide hydrolase N-Acylethanolamine Genetics Animals Endogenous quantification Heavy-labeled precursor Molecular Biology chemistry.chemical_classification Fatty acid amide Fatty acid Lipid metabolism Cell Biology Long-chain fatty acid amide Lipid Metabolism 3. Good health Biosynthetic pathway Drosophila melanogaster chemistry Ethanolamines Long chain fatty acid |
| Zdroj: | FEBS Letters. 588:1596-1602 |
| ISSN: | 0014-5793 |
| Popis: | Long-chain fatty acid amides are cell-signaling lipids identified in mammals and, recently, in invertebrates, as well. Many details regarding fatty acid amide metabolism remain unclear. Herein, we demonstrate that Drosophila melanogaster is an excellent model system for the study long-chain fatty acid amide metabolism as we have quantified the endogenous levels of N-acylglycines, N-acyldopamines, N-acylethanolamines, and primary fatty acid amides by LC/QTOF-MS. Growth of D. melanogaster on media supplemented with [1-13C]-palmitate lead to a family of 13C-palmitate-labeled fatty acid amides in the fly heads. The [1-13C]-palmitate feeding studies provide insight into the biosynthesis of the fatty acid amides. |
| Databáze: | OpenAIRE |
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