OESTROGEN DYNAMICS IN ADRENAL VENOUS EFFLUENTS IN CONGENITAL VIRILIZING ADRENAL HYPERPLASIA
| Autor: | S. S. Achando, Bernardo Léo Wajchenberg, Jayme Goldman, Y. L. Thomsen, S. S. Lima, T. S. Kyan |
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| Rok vydání: | 1980 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Estrone Endocrinology Diabetes and Metabolism Stimulation Dexamethasone Veins Endocrinology Internal medicine Adrenal Glands Humans Medicine Congenital adrenal hyperplasia Child Adrenal Hyperplasia Congenital Estradiol business.industry Sequential test Venous blood Hyperplasia medicine.disease Peripheral blood Peripheral Cosyntropin Female business medicine.drug |
| Zdroj: | Clinical Endocrinology. 13:401-404 |
| ISSN: | 1365-2265 0300-0664 |
| DOI: | 10.1111/j.1365-2265.1980.tb03402.x |
| Popis: | SUMMARY Four patients with untreated congenital virilizing adrenal hyper-plasia (partial 21-hydroxylase deficiency) were studied by bilateral adrenal vein catheterization. Simultaneous right and left adrenal and peripheral blood samples were collected for determination of oestrone (E1) and oestradiol (E2. The concentrations of both were higher in the adrenal effluents than in the peripheral blood samples, indicating their secretion by the adrenals. All patients were also studied during a sequential test of suppression (0.5 h after i.v. administration of 4 mg dexamethasone) and stimulation (5 min after i.v. administration of 250 μg ACTH 1–24; Synacthen). Mean peripheral E2 concentrations did not change significantly whereas E1 increased above control levels after stimulation. In contrast, suppression of adrenal venous blood concentrations with dexamethasone, and stimulation with ACTH, was demonstrated for every patient. The results indicate that in congenital adrenal hyperplasia the adrenal glands secrete significant amounts of E1 and E2. |
| Databáze: | OpenAIRE |
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