The vanilloid receptor as a putative target of diverse chemicals in multiple chemical sensitivity
| Autor: | Martin L. Pall, Julius H. Anderson |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
N-Methylaspartate
Sick Building Syndrome Chemical compound TRPV1 TRPV Cation Channels Pharmacology Nitric Acid Nitric oxide chemistry.chemical_compound Peroxynitrous Acid medicine Environmental Chemistry Humans Receptor General Environmental Science Public Health Environmental and Occupational Health Glutamate receptor Fungi Environmental Exposure humanities medicine.anatomical_structure nervous system chemistry Biochemistry Peripheral nervous system NMDA receptor Multiple Chemical Sensitivity Peroxynitrite |
| Zdroj: | Archives of environmental health. 59(7) |
| ISSN: | 0003-9896 |
| Popis: | The vanilloid receptor (TRPV1 or VR1), widely distributed in the central and peripheral nervous system, is activated by a broad range of chemicals similar to those implicated in Multiple Chemical Sensitivity (MCS) Syndrome. The vanilloid receptor is reportedly hyperresponsive in MCS and can increase nitric oxide levels and stimulate N-methyl-D-aspartate (NMDA) receptor activity, both of which are important features in the previously proposed central role of nitric oxide and NMDA receptors in MCS. Vanilloid receptor activity is markedly altered by multiple mechanisms, possibly providing an explanation for the increased activity in MCS and symptom masking by previous chemical exposure. Activation of this receptor by certain mycotoxins may account for some cases of sick building syndrome, a frequent precursor of MCS. Twelve types of evidence implicate the vanilloid receptor as the major target of chemicals, including volatile organic solvents (but not pesticides) in MCS. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|