Effects of MTNR1B Genetic Variants on Individual Susceptibility to Gestational Diabetes Mellitus: A Meta-Analysis
| Autor: | Guangliang Jia, Yanxiang Gao, Yanqin Zhang, Chunzhi Li |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Oncology
Genetic Markers medicine.medical_specialty MEDLINE 03 medical and health sciences 0302 clinical medicine Pregnancy Internal medicine Medicine Humans Genetic Predisposition to Disease 030219 obstetrics & reproductive medicine Individual susceptibility business.industry Receptor Melatonin MT2 Genetic variants Obstetrics and Gynecology Genetic Variation Odds ratio medicine.disease Confidence interval Gestational diabetes Diabetes Gestational Melatonin receptor 1B Meta-analysis Pediatrics Perinatology and Child Health Female business |
| Zdroj: | American journal of perinatology. 37(6) |
| ISSN: | 1098-8785 |
| Popis: | Objective Whether melatonin receptor 1B (MTNR1B) variants are implicated in gestational diabetes mellitus (GDM) remains unclear. Therefore, we performed this meta-analysis to obtain a more conclusive result on associations between MTNR1B variants and GDM. Study Design Literature research was performed in PubMed, Web of Science, Embase, and China National Knowledge Infrastructure. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. Results A total of 17 studies were eligible for analyses. Pooled overall analyses showed that rs1387153 (dominant model: p = 0.0002, OR = 0.78, 95% CI: 0.68–0.89; recessive model: p Conclusion Our findings indicated that MTNR1B rs1387153, rs4753426, and rs10830963 variants might serve as genetic biomarkers of GDM. |
| Databáze: | OpenAIRE |
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