Relationship Between Short-Term Blood Pressure Variability and Subclinical Renal Damage in Essential Hypertensive Patients
| Autor: | Maria Giovanna Vario, Giovanni Cerasola, Miriam Costanzo, Giuseppe Mulè, Santina Cottone, Laura Guarino, Anna Carola Foraci, Ilenia Calcaterra, Giulio Geraci |
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| Přispěvatelé: | Mulè, G., Calcaterra, I., Costanzo, M., Geraci, G., Guarino, L., Foraci, A., Vario, M., Cerasola, G., Cottone, S. |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Settore MED/09 - Medicina Interna Ambulatory blood pressure Endocrinology Diabetes and Metabolism Renal function Blood Pressure Essential hypertension renal dysfunction Internal medicine CKD Internal Medicine Albuminuria Humans Medicine Subclinical infection Settore MED/14 - Nefrologia business.industry Blood Pressure Monitoring Ambulatory Middle Aged medicine.disease Original Papers Settore MED/11 - Malattie Dell'Apparato Cardiovascolare ambulatory blood pressure monitoring Endocrinology Blood pressure Hypertension blood pressure variability albuminuria Ambulatory Cardiology Female Kidney Diseases Microalbuminuria Essential Hypertension Cardiology and Cardiovascular Medicine business Glomerular Filtration Rate Kidney disease |
| Zdroj: | J Clin Hypertens (Greenwich) |
| ISSN: | 1524-6175 |
| DOI: | 10.1111/jch.12534 |
| Popis: | The authors aimed to analyze the relationship between subclinical renal damage, defined as the presence of microalbuminuria or an estimated glomerular filtration rate (eGFR) between 30mL/min/1.73m(2) and 60mL/min/1.73m(2) and short-term blood pressure (BP) variability, assessed as average real variability (ARV), weighted standard deviation (SD) of 24-hour BP, and SD of daytime and nighttime BP. A total of 328 hypertensive patients underwent 24-hour ambulatory BP monitoring, 24-hour albumin excretion rate determination, and eGFR calculation using the Chronic Kidney Disease Epidemiology Collaboration equation. ARV of 24-hour systolic BP (SBP) was significantly higher in patients with subclinical renal damage (P=.001). This association held (P=.04) after adjustment for potential confounders. In patients with microalbuminuria, ARV of 24-hour SBP, weighted SD of 24-hour SBP, and SD of daytime SBP were also independently and inversely related to eGFR. These results seem to suggest that in essential hypertension, short-term BP variability is independently associated with early renal abnormalities. |
| Databáze: | OpenAIRE |
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