Influence of Annona muricata (soursop) on biodistribution of radiopharmaceuticals in rats
| Autor: | Flora Tamires Moura Bandeira, Vanessa Santos de Arruda Barbosa, Delianne Azevedo Barbosa, Cecília Maria de Carvalho Xavier Holanda, Vanessa Fávero Demeda, Aldo Cunha Medeiros, Kércia Regina Santos Gomes Pereira, Hilkéa Carla Souza de Medeiros |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Biodistribution Phytic Acid RD1-811 Sodium Urinary Bladder chemistry.chemical_element Biological Availability Spleen Pharmacology Kidney Annona medicine Animals Drug Interactions Tissue Distribution Rats Wistar Annona muricata biology Plant Extracts business.industry biology.organism_classification Surgery Rats medicine.anatomical_structure chemistry Dimercaptosuccinic acid Technetium Tc 99m Dimercaptosuccinic Acid Radiopharmaceuticals business medicine.drug |
| Zdroj: | Acta Cirurgica Brasileira, Vol 29, Iss 3, Pp 145-150 (2014) Acta Cirúrgica Brasileira v.29 n.3 2014 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Volume: 29, Issue: 3, Pages: 145-150, Published: MAR 2014 |
| ISSN: | 0102-8650 |
| Popis: | PURPOSE: To evaluate the effect of hydroalcoholic extract of A. muricata on biodistribution of two radiopharmaceuticals: sodium phytate and dimercaptosuccinic acid (DMSA), both labeled with 99mtechnetium.METHODS: Twenty four Wistar rats were divided into two treated groups and two controls groups. The controls received water and the treated received 25mg/kg/day of A. muricata by gavage for ten days. One hour after the last dose, the first treated group received 99mTc-DMSA and the second sodium 99mTc-phytate (0.66MBq each group), both via orbital plexus. Controls followed the same protocol. Forty min later, all groups were sacrificed and the blood, kidney and bladder were isolated from the first treated group and the blood, spleen and liver isolated from the second treated group. The percentage of radioactivity per gram of tissue (%ATI/g) was calculated using a gamma counter.RESULTS: The statistical analysis showed that there was a statistically significant decrease (p |
| Databáze: | OpenAIRE |
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