Immune reactivity of women on hormonal contraceptives
| Autor: | G. Gerretsen, J. Kremer, J.P. Nater, E. Bleumink, G.C. de Gast, T.H. The |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
medicine.medical_specialty
Progestogen business.industry Lymphocyte medicine.medical_treatment Obstetrics and Gynecology Clinical research medicine.anatomical_structure Immune system Endocrinology Reproductive Medicine Pill Megestrol acetate Internal medicine Follicular phase Norgestrel medicine Medroxyprogesterone acetate Levonorgestrel business Sensitization medicine.drug Hormone |
| Zdroj: | Contraception. 22:25-29 |
| ISSN: | 0010-7824 |
| DOI: | 10.1016/0010-7824(80)90114-6 |
| Popis: | To investigate the influence of sex-steroids on the in vitro correlate of cell-mediated immunity (CMI), blood samples from 49 women on hormonal contraceptives were tested on the lymphocyte response to the mitogens phytohemagglutinin (PHA) and concanavalin A (Con-A). Sixteen women were taking oral contraceptives of combined oestrogen/progestogen of the same brand (low oestrogenic and middle range progestogenic activity); 15 had received intramuscular injections of medroxyprogesterone acetate and 18 women were using a sequential pill. The results were compared with those of 18 women not taking contraceptive steroids and matched for age. No significant changes were observed between the different groups. Considering the previously found alterations in dinitrochlorobenzene (DNCB) skin test reactivity by sex steroids, it is hypothesized that sex-steroids have little or no influence on the central proliferative phase of the immune response, but have a profound effect on the efferent phase. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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