Metabolic cooperation between mouse embryonal carcinoma cells and their differentiated derivatives

Autor: Jean-François Nicolas, H Jakob, Francis Jacob
Přispěvatelé: Génétique cellulaire, Institut Pasteur [Paris]-Centre National de la Recherche Scientifique (CNRS), Institut Pasteur [Paris] (IP)-Centre National de la Recherche Scientifique (CNRS)
Jazyk: angličtina
Rok vydání: 1978
Předmět:
MESH: Cell Differentiation
Cell signaling
Cell type
Hypoxanthine Phosphoribosyltransferase
genetic structures
Cellular differentiation
[SDV]Life Sciences [q-bio]
[SDV.CAN]Life Sciences [q-bio]/Cancer
Cell Communication
Biology
Hybrid Cells
MESH: Hybrid Cells/metabolism
MESH: Cell Adhesion
Cell Line
Embryonal carcinoma
03 medical and health sciences
MESH: Cell Communication
medicine
Cell Adhesion
Cell adhesion
[SDV.BDD]Life Sciences [q-bio]/Development Biology
030304 developmental biology
MESH: Neoplasms
Experimental/metabolism
0303 health sciences
Multidisciplinary
MESH: Teratoma/metabolism
MESH: Teratoma/pathology
030302 biochemistry & molecular biology
Teratoma
Cell Differentiation
Neoplasms
Experimental
MESH: Hypoxanthine Phosphoribosyltransferase/metabolism
medicine.disease
In vitro
Cell biology
MESH: Cell Line
Culture Media
Teratocarcinoma
Cell culture
MESH: Culture Media
Research Article
Zdroj: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, National Academy of Sciences, 1978, 75 (7), pp.3292-6. ⟨10.1073/pnas.75.7.3292⟩
Proceedings of the National Academy of Sciences of the United States of America, 1978, 75 (7), pp.3292-6. ⟨10.1073/pnas.75.7.3292⟩
ISSN: 0027-8424
1091-6490
DOI: 10.1073/pnas.75.7.3292⟩
Popis: International audience; Metabolic cooperation has been used as an index of intercellular communication between mouse embryonal carcinoma (EC) and other cell types. EC cells do not cooperate with differentiated cells of various properties or origins. In contrast they cooperate with cells of all other EC lines tested, including a human teratocarcinoma line, but with different efficiencies. This might reflect differences either in cell-cell interactions or in the formation of gap junctions. During in vitro differentiation, EC cells appear to remain isolated from differentiated cell types.
Databáze: OpenAIRE
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