Small Molecules Drive Big Improvements in Immuno-Oncology Therapies
| Autor: | Bayard R. Huck, Klaus Urbahns, Lisa Kötzner |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Combination therapy Immune checkpoint inhibitors Reviews Antineoplastic Agents Review Catalysis combination therapy Small Molecule Libraries 03 medical and health sciences 0302 clinical medicine Neoplasms Internal medicine medicine kinase inhibitors Humans business.industry T-cells Cancer General Chemistry medicine.disease Small molecule Blockade small molecules checkpoint inhibitor 030104 developmental biology Drug Design 030220 oncology & carcinogenesis Immunotherapy business |
| Zdroj: | Angewandte Chemie (International Ed. in English) |
| ISSN: | 1433-7851 |
| DOI: | 10.1002/anie.201707816 |
| Popis: | Immuno‐oncology therapies have the potential to revolutionize the armamentarium of available cancer treatments. To further improve clinical response rates, researchers are looking for novel combination regimens, with checkpoint blockade being used as a backbone of the treatment. This Review highlights the significance of small molecules in this approach, which holds promise to provide increased benefit to cancer patients. |
| Databáze: | OpenAIRE |
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