Relations between personality changes and cerebrospinal fluid biomarkers of Alzheimer's disease pathology

Autor: Hugues Henry, A. Von Gunten, Julius Popp, Jean-Philippe Antonietti, Domilė Tautvydaitė
Rok vydání: 2017
Předmět:
Male
Pathology
medicine.medical_specialty
Personality Inventory
media_common.quotation_subject
tau Proteins
Personality Disorders
Revised NEO Personality Inventory
03 medical and health sciences
Personality changes
0302 clinical medicine
Alzheimer Disease
medicine
Humans
Personality
Biomarkers/cerebrospinal fluid
Aged
Aged
80 and over
Alzheimer Disease/cerebrospinal fluid
Alzheimer Disease/complications
Alzheimer Disease/pathology
Amyloid beta-Peptides/cerebrospinal fluid
Female
Middle Aged
Peptide Fragments/cerebrospinal fluid
Personality Disorders/etiology
Psychiatric Status Rating Scales
Regression Analysis
tau Proteins/cerebrospinal fluid
Alzheimer's disease (AD)
Cerebrospinal fluid biomarkers
Mild cognitive impairment (MCI)
Revised NEO Personality Inventory (NEO-PI-R)
Alzheimer Disease/cerebrospinal fluid/complications/pathology
Big Five personality traits
Biological Psychiatry
media_common
Amyloid beta-Peptides
030214 geriatrics
medicine.disease
Neuroticism
Personality disorders
Peptide Fragments
3. Good health
Psychiatry and Mental health
Personality Assessment Inventory
Psychology
Biomarkers
030217 neurology & neurosurgery
Zdroj: Journal of psychiatric research
Journal of Psychiatric Research, Vol. 90 (2017) pp. 12-20
Journal of psychiatric research, vol. 90, pp. 12-20
ISSN: 0022-3956
DOI: 10.1016/j.jpsychires.2016.12.024
Popis: Specific changes in personality profiles may represent early non-cognitive symptoms of Alzheimer's disease (AD). Evaluating the subject's personality changes may add significant clinical information, as well as help to better understand the interaction between personality change, cognitive decline, and cerebral pathology. With this study we aimed to describe the relationship between personality changes and cerebrospinal fluid (CSF) markers of AD pathology at early clinical stages of the disease. One hundred and ten subjects, of whom 66 cognitively impaired patients (57 with mild cognitive impairment (MCI), and 9 with mild dementia) and 44 healthy controls, had neuropsychological examination as well as lumbar puncture to determine concentrations of CSF biomarkers of AD pathology (amyloid beta javax.xml.bind.JAXBElement@6dd80402 (Aβ javax.xml.bind.JAXBElement@750f1490 ), phosphorylated tau (ptau-181), and total-tau (tau)). The Revised NEO Personality Inventory (NEO-PI-R) was administered twice, once to evaluate subjects' current personality and once to assess personality traits retrospectively 5 years before evaluation. Subjects with an AD CSF biomarker profile showed significant increase in neuroticism and decrease in conscientiousness over time as compared to non-AD CSF biomarker group. In regression analysis controlling for global cognition as measured by the MMSE score, increasing neuroticism and decreasing extraversion, openness to experience and conscientiousness were associated with lower Aβ javax.xml.bind.JAXBElement@71367816 concentrations but not with tau and ptau-181 concentrations. Our findings suggest that early and specific changes in personality are associated with cerebral AD pathology. Concentrations of CSF biomarkers, additionally to severity of the cognitive impairment, significantly contribute in predicting specific personality changes.
Databáze: OpenAIRE
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