Langerhans cells (CD1a and CD207), dermal dendrocytes (FXIIIa) and plasmacytoid dendritic cells (CD123) in skin lesions of leprosy patients
| Autor: | Luciana Mota Silva, Tinara Leila de Sousa Aarão, Juarez Antônio Simões Quaresma, Francisca Regina Oliveira Carneiro, Jorge Rodrigues de Sousa, Kelly Emi Hirai, Leônidas Braga Dias, Juarez de Souza, Hellen Thais Fuzii |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Langerhans cell Interleukin-3 Receptor alpha Subunit Tuberculoid leprosy Microbiology Antigens CD1 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Immune system Antigens CD Leprosy Immunopathology medicine Humans Lectins C-Type Mycobacterium leprae Skin Lepromatous leprosy integumentary system biology Follicular dendritic cells Dendritic Cells Dermis biology.organism_classification medicine.disease Acquired immune system Mannose-Binding Lectins 030104 developmental biology Infectious Diseases medicine.anatomical_structure Langerhans Cells Immunology Factor XIIIa |
| Zdroj: | Microbial Pathogenesis. 91:18-25 |
| ISSN: | 0882-4010 |
| Popis: | The clinical course of infection with Mycobacterium leprae varies widely and depends on the pattern of the host immune response. Dendritic cells play an important role in the activation of the innate and adaptive immune system and seem to be essential for the development of the disease. To analyze the presence of epidermal dendritic cells (CD1a and CD207), plasmacytoid dendritic cells (CD123) and dermal dendrocytes (factor XIIIa) in lesion fragments of leprosy patients, skin samples from 30 patients were studied. These samples were submitted to immunohistochemistry against CD1a, CD207, FXIIIa, and CD123. The results showed a larger number of Langerhans cells, detected with the CD1a or CD207 marker, dermal dendrocytes and plasmacytoid dendritic cells in patients with the tuberculoid form. A positive correlation was observed between the Langerhans cell markers CD1a and CD207 in both the tuberculoid and lepromatous forms, and between Langerhans cells and dermal dendrocytes in samples with the tuberculoid form. The present results indicate the existence of a larger number of dendritic cells in patients at the resistant pole of the disease (tuberculoid) and suggest that the different dendritic cells studied play a role, favoring an efficient immune response against infection with M. leprae. |
| Databáze: | OpenAIRE |
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