SMOKING, RURAL RESIDENCE AND DIABETES AS RISK FACTORS FOR PRESUMED OCULAR HISTOPLASMOSIS SYNDROME
| Autor: | Gordon Jacobsen, David Y. Lu, Scott C. Richards, Brad F. Richey, Zachary M. Gee, Rachel S. Obrock |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
Rural Population medicine.medical_specialty Indiana genetic structures Presumed ocular histoplasmosis syndrome case-control study Visual Acuity smoking Retinal Diseases Risk Factors Diabetes mellitus Internal medicine medicine Diabetes Mellitus rural residence Humans In patient Original Study Fluorescein Angiography Histoplasmosis Retrospective Studies Adult patients diabetes business.industry Medical record General Medicine Choroid Diseases urbanicity Middle Aged medicine.disease eye diseases Choroidal Neovascularization Ophthalmology Choroidal neovascularization Increased risk Case-Control Studies Residence epidemiology Female sense organs medicine.symptom business presumed ocular histoplasmosis syndrome Eye Infections Fungal |
| Zdroj: | Retina (Philadelphia, Pa.) |
| ISSN: | 1539-2864 0275-004X |
| Popis: | Smoking and rural residence are independently correlated with the development of presumed ocular histoplasmosis syndrome, both with and without choroidal neovascularization. Diabetes may also be correlated with ocular histoplasmosis without choroidal neovascularization. Purpose: To investigate the relationship of smoking, urbanicity, and diabetes to presumed ocular histoplasmosis syndrome (POHS) and associated choroidal neovascularization (CNV). Methods: Medical records of 751 adult patients with POHS were reviewed, including 603 patients without CNV and 148 patients with CNV. Age-matched and gender-matched controls were randomly selected from the same practice for comparison. Statistical comparisons of smoking history, urbanicity, and diabetic history were performed using chi-square and conditional logistic regression analyses. Results: Increased rates of current or former smoking, rural residence, and diabetes were found in patients with POHS compared with controls. POHS patients with CNV had increased rates of current or former smoking and rural residence as compared with controls. Conclusion: A history of current or past smoking is associated with an increased risk of developing both POHS alone and POHS with CNV. We did not find a significant additional risk of smoking on the development of CNV in patients with POHS. Patients living in rural locations are more likely than those in urban locations to develop both POHS and POHS with CNV. Diabetics may be more likely to develop POHS than nondiabetics. |
| Databáze: | OpenAIRE |
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