Polyacetylene and phenolic constituents from the roots of Codonopsis javanica
| Autor: | Tran Thi Hong Hanh, Nguyen Thi Dieu Thuan, Nguyen Xuan Cuong, Tran Hong Quang, Nguyen Hoai Nam, Chau Van Minh, Pham Van Huyen, Nguyen Huu Toan Phan, Nguyen Huu Huong Duyen, Nguyen Thi Hien |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Campanulaceae biology Traditional medicine 010405 organic chemistry Organic Chemistry Glycoside Plant Science biology.organism_classification Codonopsis javanica 01 natural sciences Biochemistry 0104 chemical sciences Analytical Chemistry 010404 medicinal & biomolecular chemistry Polyacetylene chemistry.chemical_compound chemistry Campanumoea javanica |
| Zdroj: | Natural Product Research. 36:2314-2320 |
| ISSN: | 1478-6427 1478-6419 |
| DOI: | 10.1080/14786419.2020.1833200 |
| Popis: | Chemical investigation of the roots of Codonopsis javanica resulted in isolation of 12 compounds, including one new polyacetylene, codojavanyol (1), one new phenolic glycoside, codobenzyloside (7), and 10 known compounds, (2E,8E)-9-(tetrahydro-2H-pyran-2-yl)nona-2,8-diene-4,6-diyl-1-ol (2), lobetyol (3), lobetyolin (4), lobetyolinin (5), cordifolioidyne B (6), benzyl-α-L-arabinopyranosyl (1-6)-β-D-glucopyranoside (8), (Z)-8-β-D-glucopyranosyloxycinnamic acid (9), syringin (10), syringaresinol (11), and tryptophan (12). Their structures were elucidated by 1 D and 2 D NMR and MS spectroscopic analyses in comparison with the data reported in the literature. The stereochemistry of the C-2′ position of 1 was identified based on time-dependent density functional theory (TDDFT) electronic circular dichroism (ECD) calculation. Among the isolates, compounds 3-5 were shown to have weak cytotoxicity toward three human carcinoma cell lines, including lung (A549), liver (HepG2), and breast (MCF7), with the induction of 41.4 to 55.6% cell death at the concentration of 100 µM. |
| Databáze: | OpenAIRE |
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