Analysis of miRNA expression profiling identifies miR-214-3p as a novel biomarker in sinonasal inverted papilloma
| Autor: | Yong Li, Yaoshu Teng, Xiaolin Cao, Fengchun Lin, Yueqiu Gao, Yuandong Li, Zhihong Lin, Xiangyu Lou |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Cancer Research Cell signaling Microarray Carcinogenesis Nose Neoplasms Inverted papilloma Down-Regulation Computational biology Biology medicine.disease_cause 03 medical and health sciences 0302 clinical medicine Downregulation and upregulation microRNA Genetics medicine Biomarkers Tumor Humans 030223 otorhinolaryngology miR-214 Gene Aged Aged 80 and over Papilloma Inverted Computational Biology Middle Aged medicine.disease Up-Regulation Gene Expression Regulation Neoplastic MicroRNAs 030220 oncology & carcinogenesis Female |
| Zdroj: | Epigenomics. 10(12) |
| ISSN: | 1750-192X |
| Popis: | Aim: To analyze the expression profile, diagnostic and clinicopathological significances of miRNAs in sinonasal inverted papilloma (SNIP). Materials & methods: The expression profile of miRNAs was analyzed using a miRNA microarray approach. The potential functions and clinical significances of specific miRNAs were further analyzed by bioinformatics and statistical methods. Results: The microarray assay identified 37 significantly upregulated and 21 downregulated miRNAs in SNIP. Of nine miRNAs randomly selected, the expression levels of seven miRNAs were confirmed by quantitative real-time PCR. The potential target genes of several candidate miRNAs were enriched in some biological processes and cellular signaling pathways related to tumorigenesis. Receiever operating characteristic curve analysis for miR-214-3p indicated an area under the curve of 0.932. Notably, its expression level was significantly decreased in SNIP tissues and associated with SNIP staging and recurrence. Conclusion: MiR-214-3p can possibly serve as a valuable biomarker and a therapeutic target for SNIP. |
| Databáze: | OpenAIRE |
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