Alanine aminotransferase and gamma-glutamyl transferase are associated with the metabolic syndrome but not with angiographically determined coronary atherosclerosis
| Autor: | Philipp Rein, Christian Boehnel, Vlado Jankovic, Christoph H. Saely, Alexander Vonbank, Heinz Drexel, Stefan Aczel, Stefan Beer, Lorenz Risch, M. Woess |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Very low-density lipoprotein Clinical Biochemistry Lumen (anatomy) Coronary Artery Disease Coronary Angiography digestive system Biochemistry Gastroenterology Coronary artery disease Internal medicine medicine Humans Aspartate Aminotransferases Gamma-glutamyltransferase Alanine aminotransferase Coronary atherosclerosis Aged Metabolic Syndrome biology business.industry Biochemistry (medical) Alanine Transaminase General Medicine gamma-Glutamyltransferase Middle Aged medicine.disease digestive system diseases Endocrinology Alanine transaminase Liver biology.protein Female Metabolic syndrome business Biomarkers |
| Zdroj: | Clinica chimica acta; international journal of clinical chemistry. 397(1-2) |
| ISSN: | 0009-8981 |
| Popis: | Recently, elevated liver enzymes have attracted great interest as potential novel markers of cardiovascular risk. Their association with angiographically determined coronary artery disease (CAD) is unknown.We enrolled 1000 consecutive patients undergoing coronary angiography for the evaluation of suspected or established stable CAD. The metabolic syndrome (MetS) was defined according to ATP-III criteria; significant CAD was diagnosed in the presence of coronary stenoses with lumen narrowingor=50%.Serum alanine aminotransferase (ALT), the ALT/aspartate aminotransferase (AST) ratio, and serum gamma-glutamyl transferase (GGT) were significantly higher in patients with the MetS than in subjects without the MetS (34+/-21 vs. 29+/-20 U/l; p0.001, 1.16+/-0.39 vs. 1.00+/-0.36 U/l, p0.001; and 53+/-88 vs. 43+/-57 U/l, p=0.001, respectively) but were similar in patients with significant CAD as in those who did not have significant CAD at angiography (p=0.592; p=0.731, and p=0.716, respectively). Analysis of covariance after multivariate adjustment including alcohol consumption confirmed that ALT, ALT/AST ratio, and GGT were significantly and independently associated with the MetS but not with significant CAD.ALT, the ALT/AST ratio, and GGT are associated with the MetS but not with angiographically determined coronary atherosclerosis. |
| Databáze: | OpenAIRE |
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