Comparison of the Prognostic Value of Ki-67 and Programmed Cell Death Ligand-1 in Patients with Upper Tract Urothelial Carcinoma
| Autor: | Chien-Hsu Chen, Eing-Mei Tsai, Shun-Chen Huang, Ping-Chia Chiang, Po-Hui Chiang, Ming-Tse Sung, Mu-Yao Tsai, Jau-Ling Suen |
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| Rok vydání: | 2021 |
| Předmět: |
Programmed cell death
medicine.medical_specialty Necrosis Value (computer science) Gastroenterology Article radical nephroureterectomy Internal medicine combined positive score medicine In patient programmed cell death ligand-1 Pathological biology business.industry General Medicine upper tract urothelial carcinoma Ki-67 biology.protein Medicine T-stage Immunohistochemistry medicine.symptom business |
| Zdroj: | Journal of Clinical Medicine Volume 10 Issue 16 Journal of Clinical Medicine, Vol 10, Iss 3728, p 3728 (2021) |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm10163728 |
| Popis: | We retrospectively enrolled 102 patients with upper tract urothelial carcinoma (UTUC) who underwent radical nephroureterectomy to examine the prognostic value of Ki-67 and programmed cell death ligand-1 (PD-L1). Then, we performed PD-L1 and Ki-67 immunohistochemical staining on whole tissue sections. The cut-off value of PD-L1 positivity was a combined positive score (CPS) ≥10 and the Ki-67 overexpression was 20%. Among the 102 patients, 16.7% and 48.0% showed positive PD-L1 expression and Ki-67 overexpression, respectively. A CPS ≥10 was significantly associated with a higher pathological T stage (p = 0.049). In addition, Ki-67 overexpression was significantly associated with a pathological T stage ≥ 2 (p = 0.027) and tumour necrosis (p = 0.016). In the multivariable analysis, a positive PD-L1 expression was significantly correlated with worse cancer-specific survival (HR = 3.66, 95% CI =1.37−9.77, p = 0.01). However, there was no predictive value using a combination of PD-L1 expression and Ki-67 overexpression as a prognostic predictor. Compared with Ki-67 overexpression, a positive PD-L1 expression with CPS ≥ 10 was a stronger independent prognostic factor for CSS in patients with UTUC. |
| Databáze: | OpenAIRE |
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