Remote F-wave changes after local botulinum toxin application
| Autor: | Kai Wohlfarth, Beate Rothe, Reinhard Dengler, Margot Schubert, Josef Elek |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Adult
Male Time Factors Muscle spindle Neuromuscular transmission Action Potentials Nerve conduction velocity F wave Physiology (medical) medicine Humans Botulinum Toxins Type A Ulnar nerve Muscle Skeletal Torticollis Ulnar Nerve business.industry Peroneal Nerve Anatomy Middle Aged Botulinum toxin Sensory Systems body regions medicine.anatomical_structure Neurology Dystonic Disorders Anesthesia Female Neurology (clinical) medicine.symptom business Dystonic disorder medicine.drug Muscle contraction Muscle Contraction |
| Zdroj: | Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 112(4) |
| ISSN: | 1388-2457 |
| Popis: | Objective : Although the therapeutic effects of botulinum toxin A can be explained by its action at the neuromuscular junction, central or more proximal effects have also been discussed. Methods : Eleven patients with torticollis spasmodicus and 3 patients with writer's cramp were studied before and 1 and 5 weeks after the first treatment with botulinum toxin. We measured compound muscle action potentials (CMAPs), motor conduction velocities (MCVs), the shortest (SFL) and the mean F-wave latencies (MFL) and F-wave persistence (30 trials) of untreated muscles for each side (ulnar nerve-abductor digiti minimi muscle, peroneal nerve-tibialis anterior muscle). Results : CMAPs and MCVs showed no significant changes. For both nerves, however, SFL and MFL were prolonged slightly 1 week after treatment and returned to about baseline after 5 weeks ( t test). The F-wave persistence was reduced 1 week after treatment for the right ulnar and both peroneal nerves ( t test). Conclusions : These results are not likely due to an impairment of neuromuscular transmission. Instead, we propose a decreased excitability of α-motoneurons supplying non-treated muscles. A reduction of muscle spindle activity or changes of the recurrent inhibition are discussed as possible causes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect