Association between skeletal muscle mass and serum concentrations of lipoprotein lipase, GPIHBP1, and hepatic triglyceride lipase in young Japanese men

Autor: Nobuo Kotajima, Katsuyuki Nakajima, Takao Kimura, Shingo Matsumoto, Masami Murakami, Ryutaro Matsumoto, Katsuhiko Tsunekawa, Yoshifumi Shoho, Yoshimaro Yanagawa, Osamu Araki
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Male
Endocrinology
Diabetes and Metabolism
Clinical Biochemistry
Lipoprotein lipase (LPL)
Thyroid Function Tests
030204 cardiovascular system & hematology
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
lcsh:RC620-627
Lipoprotein lipase
Triglyceride lipase
GPIHBP1
Hepatic triglyceride lipase (HTGL)
lcsh:Nutritional diseases. Deficiency diseases
medicine.anatomical_structure
Liver
Female
lipids (amino acids
peptides
and proteins)
Adult
medicine.medical_specialty
Glycosylphosphatidylinositol anchored high-density lipoprotein binding protein 1 (GPIHBP1)
Adolescent
Clinical chemistry
030209 endocrinology & metabolism
Young Adult
03 medical and health sciences
Skeletal muscle mass
Muscular Diseases
Internal medicine
medicine
Humans
Muscle
Skeletal
Exercise
Genetic Association Studies
Triglycerides
Receptors
Lipoprotein
Triglyceride
business.industry
Research
Biochemistry (medical)
Skeletal muscle
Cholesterol
LDL
Lipase
Lipid Metabolism
medicine.disease
Thyroid hormone
Lipoprotein Lipase
chemistry
Athletes
Sarcopenia
Energy Metabolism
business
Lipoprotein
Zdroj: Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-9 (2019)
Lipids in Health and Disease
DOI: 10.1186/s12944-019-1014-7
Popis: Background Two important regulators for circulating lipid metabolisms are lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL). In relation to this, glycosylphosphatidylinositol anchored high-density lipoprotein binding protein 1 (GPIHBP1) has been shown to have a vital role in LPL lipolytic processing. However, the relationships between skeletal muscle mass and lipid metabolism, including LPL, GPIHBP1, and HTGL, remain to be elucidated. Demonstration of these relationships may lead to clarification of the metabolic dysfunctions caused by sarcopenia. In this study, these relationships were investigated in young Japanese men who had no age-related factors; participants included wrestling athletes with abundant skeletal muscle. Methods A total of 111 young Japanese men who were not taking medications were enrolled; 70 wrestling athletes and 41 control students were included. The participants’ body compositions, serum concentrations of lipoprotein, LPL, GPIHBP1 and HTGL and thyroid function test results were determined under conditions of no extreme dietary restrictions and exercises. Results Compared with the control participants, wrestling athletes had significantly higher skeletal muscle index (SMI) (p
Databáze: OpenAIRE
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