Ocular brachytherapy dosimetry for 103Pd and 125I in the presence of gold nanoparticles: a Monte Carlo study

Autor: Somayeh Asadi, Mehdi Vaez-zadeh, Mohammad Vahidian, Mahdieh Marghchouei, S. Farhad Masoudi
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Choroidal melanoma
Organs at Risk
medicine.medical_treatment
Monte Carlo method
Brachytherapy
Metal Nanoparticles
030218 nuclear medicine & medical imaging
Iodine Radioisotopes
0302 clinical medicine
Instrumentation
Melanoma
Radiation
Phantoms
Imaging
Radiotherapy Dosage
Hematology
103Pd and 125I
medicine.anatomical_structure
Oncology
Radiology Nuclear Medicine and imaging
Colloidal gold
030220 oncology & carcinogenesis
Absorbed dose
Monte Carlo Method
MCNP5
Palladium
Adult
Materials science
FOS: Physical sciences
Imaging phantom
03 medical and health sciences
medicine
Dosimetry
Radiation Oncology Physics
Humans
Radiology
Nuclear Medicine and imaging
Computer Simulation
choroidal melanoma
Radiometry
business.industry
Eye Neoplasms
Water
Physics - Medical Physics
eye diseases
gold nanoparticles
Human eye
Medical Physics (physics.med-ph)
Gold
Nuclear medicine
business
Biomedical engineering
Zdroj: Journal of Applied Clinical Medical Physics
ISSN: 1526-9914
Popis: The aim of the present Monte Carlo study is to evaluate the variation of energy deposition in healthy tissues in the human eye which is irradiated by brachytherapy sources in comparison with the resultant dose increase in the gold nanoparticle(GNP)-loaded choroidal melanoma. The effects of these nanoparticles on normal tissues are compared between 103Pd and 125I as two ophthalmic brachytherapy sources. Dose distribution in the tumor and healthy tissues have been taken into account for both mentioned brachytherapy sources. Also, in a certain point of the eye, the ratio of the absorbed dose by the normal tissue in the presence of GNPs to the absorbed dose by the same point in the absence of GNPs has been calculated. In addition, differences observed in the comparison of simple water phantom and actual simulated human eye in presence of GNPs are also a matter of interest that have been considered in the present work. The results show that the calculated dose enhancement factor in the tumor for 125I is higher than that of the 103Pd. The difference between the eye globe and the water phantom is more obvious for 125I than that of the 103Pd when the ophthalmic dosimetry is done in the presence of GNPs. Whenever these nanoparticles are utilized in enhancing the absorbed dose by the eye tumor, the use of 125I brachytherapy source will greatly amplify the amount of dose enhancement factor (DEF) in the tumor site without inflicting much damage to healthy organs, when compared to the 103Pd source. Furthermore in Monte-Carlo studies of eye brachytherapy, more precise definition of the eye phantom instead of a water phantom will become increasingly important when we use 125I as opposed to when 103Pd is considered.
12 Pages, 4 Figures, Submitted to Journal Applied Clinical Physics
Databáze: OpenAIRE
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