Escalating dose, multiple binge methamphetamine regimen does not impair recognition memory in rats
| Autor: | Ronald Kuczenski, Robert E. Clark, David S. Segal |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Male
Striatal dopamine Dopamine Neuropsychological Tests Pharmacology Drug Administration Schedule Methamphetamine Rats Sprague-Dawley Cellular and Molecular Neuroscience chemistry.chemical_compound Dopamine Uptake Inhibitors medicine Animals Novel object recognition Recognition memory Analysis of Variance Behavior Animal Dose-Response Relationship Drug Potential risk Neurotoxicity Recognition Psychology Meth medicine.disease Corpus Striatum Rats Regimen Pattern Recognition Visual chemistry Anesthesia Psychology Photic Stimulation medicine.drug |
| Zdroj: | Synapse. 61:515-522 |
| ISSN: | 1098-2396 0887-4476 |
| DOI: | 10.1002/syn.20397 |
| Popis: | Rats exposed to methamphetamine (METH) in an acute high dose “binge” pattern have been reported to exhibit a persistent deficit in a novel object recognition (NOR) task, which may suggest a potential risk for human METH abusers. However, most high dose METH abusers initially use lower doses before progressively increasing the dose, only eventually engaging in multiple daily administrations. To simulate this pattern of METH exposure, we administered progressively increasing doses of METH to rats over a 14 day interval, then treated them with daily METH binges for 11 days. This treatment resulted in a persistent deficit in striatal dopamine (DA) levels of ∼20%. We then tested them in a NOR task under a variety of conditions. We could not detect a deficit in their performance in the NOR task under any of the testing conditions. These results suggest that mechanisms other than or additional to the decrement in striatal DA associated with an acute METH binge are responsible for the deficit in the NOR task, and that neuroadaptations consequential to prolonged escalating dose METH pretreatment mitigate against these mechanisms. Synapse 61:515–522, 2007. © 2007 Wiley-Liss, Inc. |
| Databáze: | OpenAIRE |
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