Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections
| Autor: | Qin Li, Jiang Gong, Jin Jing Li, Juan Chen, Wei Xu, Bo Wu, Hai Jun Deng, Kun Su, Xiaojun Tang, Xia Mao Liu, Ailong Huang, Yong Zhang, Fa Jin Lv, Fan Zhang, Jie Li Hu, Qiu Lin Shi, Quanxin Long, Jing Fu Qiu, Jun Yuan |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male 0301 basic medicine China medicine.medical_specialty Adolescent Pneumonia Viral Asymptomatic Gastroenterology General Biochemistry Genetics and Molecular Biology Serology Betacoronavirus Young Adult 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine medicine Humans Young adult Viral shedding Child Neutralizing antibody Asymptomatic Infections Pandemics Aged biology SARS-CoV-2 business.industry COVID-19 General Medicine Middle Aged medicine.disease Immunity Innate Hospitalization Pneumonia 030104 developmental biology Immunoglobulin G 030220 oncology & carcinogenesis biology.protein Cytokines Female medicine.symptom Antibody Coronavirus Infections business |
| Zdroj: | Nature Medicine |
| ISSN: | 1546-170X 1078-8956 |
| DOI: | 10.1038/s41591-020-0965-6 |
| Popis: | The clinical features and immune responses of asymptomatic individuals infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have not been well described. We studied 37 asymptomatic individuals in the Wanzhou District who were diagnosed with RT-PCR-confirmed SARS-CoV-2 infections but without any relevant clinical symptoms in the preceding 14 d and during hospitalization. Asymptomatic individuals were admitted to the government-designated Wanzhou People's Hospital for centralized isolation in accordance with policy1. The median duration of viral shedding in the asymptomatic group was 19 d (interquartile range (IQR), 15-26 d). The asymptomatic group had a significantly longer duration of viral shedding than the symptomatic group (log-rank P = 0.028). The virus-specific IgG levels in the asymptomatic group (median S/CO, 3.4; IQR, 1.6-10.7) were significantly lower (P = 0.005) relative to the symptomatic group (median S/CO, 20.5; IQR, 5.8-38.2) in the acute phase. Of asymptomatic individuals, 93.3% (28/30) and 81.1% (30/37) had reduction in IgG and neutralizing antibody levels, respectively, during the early convalescent phase, as compared to 96.8% (30/31) and 62.2% (23/37) of symptomatic patients. Forty percent of asymptomatic individuals became seronegative and 12.9% of the symptomatic group became negative for IgG in the early convalescent phase. In addition, asymptomatic individuals exhibited lower levels of 18 pro- and anti-inflammatory cytokines. These data suggest that asymptomatic individuals had a weaker immune response to SARS-CoV-2 infection. The reduction in IgG and neutralizing antibody levels in the early convalescent phase might have implications for immunity strategy and serological surveys. |
| Databáze: | OpenAIRE |
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