Reaction Crystallization of Pharmaceutical Molecular Complexes
| Autor: | Yomaira Pagán-Torres, Christopher J. Falkiewicz, Sarah J. Nehm, Kurt F. Seefeldt, Naír Rodríguez-Hornedo |
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| Rok vydání: | 2006 |
| Předmět: |
Niacinamide
Spectrophotometry Infrared Macromolecular Substances Kinetics Nucleation Pharmaceutical Science Spectrum Analysis Raman Cocrystal law.invention symbols.namesake X-Ray Diffraction law Drug Discovery Diethylcarbamazine Organic chemistry Solubility Crystallization Aqueous solution Chemistry Solubility equilibrium Models Chemical Chemical engineering Solvents symbols Molecular Medicine Microscopy Polarization Raman spectroscopy |
| Zdroj: | Molecular Pharmaceutics. 3:362-367 |
| ISSN: | 1543-8392 1543-8384 |
| DOI: | 10.1021/mp050099m |
| Popis: | A mechanism for cocrystal synthesis is reported whereby nucleation and growth of cocrystals are directed by the effect of the cocrystal components on reducing the solubility of the molecular complex to be crystallized. The carbamazepine:nicotinamide cocrystal (CBZ:NCT) was chosen as a model system to study the reaction cocrystallization pathways and kinetics in aqueous and organic solvents. Fiber optic Raman spectroscopy and Raman microscopy were used for in situ monitoring of the cocrystallization in macroscopic and microscopic scales in solutions, suspensions, slurries, and wet solid phases of cocrystal components. This study demonstrates the advantages of reaction cocrystallization methods to develop rational approaches for high-throughput screening of cocrystals that can be transferable to control batch and continuous cocrystallization processes. |
| Databáze: | OpenAIRE |
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