ATTENUATION OF PRESSOR RESPONSES TO SYMPATHETIC STIMULI IN THE RAT BY ENALAPRIL
| Autor: | Roger G King, A. L. A. Boura, E. J. N. Ishac, M. P. Rechtman, William A. W. Walters |
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| Rok vydání: | 1986 |
| Předmět: |
Male
medicine.medical_specialty Sympathetic Nervous System Physiology Blood Pressure Stimulation Norepinephrine Enalapril Physiology (medical) Internal medicine Muscarinic acetylcholine receptor medicine Animals Decerebrate State Pharmacology biology business.industry (4-(m-Chlorophenylcarbamoyloxy)-2-butynyl)trimethylammonium Chloride Rats Inbred Strains Angiotensin-converting enzyme Captopril Electric Stimulation Rats Nicotinic agonist Endocrinology Blood pressure Enzyme inhibitor biology.protein Dimethylphenylpiperazinium Iodide business hormones hormone substitutes and hormone antagonists circulatory and respiratory physiology medicine.drug |
| Zdroj: | Clinical and Experimental Pharmacology and Physiology. 13:691-697 |
| ISSN: | 1440-1681 0305-1870 |
| DOI: | 10.1111/j.1440-1681.1986.tb02398.x |
| Popis: | SUMMARY 1. Intravenous administration to pithed Wistar rats of the angiotensin converting enzyme inhibitor enalapril (0.1–1.0 mg/kg) lowered the diastolic blood pressure and reduced pressor responses occurring during electrical stimulation (1–30 Hz) of the spinal sympathetic outflow. 2. These doses of enalapril given intravenously also attenuated pressor responses to intravenous injection of the muscarinic ganglion stimulant McNeil-A-343 (50, 100, 150 μg/kg) and noradrenaline (0.1–5.0 μg/kg). Enalapril (1.0 mg/kg, i. v.) reduced pressor responses to the nicotinic ganglion stimulant 1,1-dimethyl-4-phenylpiperazinium (300 μg/kg, i.v.). 3. These results confirmed that the actions of enalapril resemble those of captopril in the pithed rat, by causing reductions in both blood pressure and pressor responses to sympathetic stimuli. |
| Databáze: | OpenAIRE |
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