African American Patients with Chronic Rhinosinusitis Have a Distinct Phenotype of Polyposis Associated with Increased Asthma Hospitalization
Autor: | Robert P. Schleimer, Mahboobeh Mahdavinia, Alan L. Landay, Whitney W. Stevens, Mohamed Benhammuda, Jill S. Jeffe, Arpita Mehta, Ali Keshavarzian, Mary C. Tobin, P. LoSavio, Sindhura Bandi, Christopher D. Codispoti, Pete S. Batra, Anju T. Peters |
---|---|
Rok vydání: | 2015 |
Předmět: |
Adult
Male medicine.medical_specialty Severity of Illness Index Article Atopy Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Nasal Polyps Hyposmia Internal medicine Severity of illness otorhinolaryngologic diseases Immunology and Allergy Medicine Humans Nasal polyps Sinusitis 030223 otorhinolaryngology Asthma Aged Retrospective Studies Rhinitis Aspirin business.industry Retrospective cohort study Atopic dermatitis respiratory system Middle Aged medicine.disease Surgery Black or African American Hospitalization Phenotype 030228 respiratory system Chronic Disease Female Illinois medicine.symptom business |
Zdroj: | The journal of allergy and clinical immunology. In practice. 4(4) |
ISSN: | 2213-2201 |
Popis: | Background Chronic rhinosinusitis (CRS) is a common inflammatory disease of the upper airways that is often categorized into subtypes including "with" and "without" nasal polyps. However, the influence of multiple important epidemiologic factors, including race, on CRS has not been investigated. Objective The present study assessed various phenotypic characteristics of CRS in patients, living in the United States, with different racial backgrounds. Methods We performed a large retrospective cohort study of patients with CRS treated at a large urban tertiary care referral center in Chicago. Results African American (AA) patients with CRS living in Chicago were more likely to report hyposmia as a symptom of CRS. Furthermore, AA patients with CRS who failed medical therapy and required surgical intervention had a significantly higher frequency of nasal polyposis and aspirin-exacerbated respiratory disease, and a higher disease severity index on computed tomography imaging than did white patients with CRS. The increased polyposis in AAs was associated with increased hospitalization for asthma. There were no differences in the prevalence of atopy, asthma, atopic dermatitis, food allergy, duration of disease, or number of surgeries between different races. Conclusions AAs with refractory CRS are at increased risk for nasal polyposis, smell loss, aspirin-exacerbated respiratory disease, and a greater severity of disease based on imaging, resulting in increased health care utilization. |
Databáze: | OpenAIRE |
Externí odkaz: |