Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018

Autor: Charles R. Beck, Nick Phin, Helen Fifer, Maya Gobin, Paddy Horner, Charles Irish, James Sedgwick, Katy Town, Daniel Gardiner, Teresa L Street, Bavithra Nathan, John Saunders, Michelle J Cole, Nicholas D Sanderson, Leanne Barker, David W Eyre, Hamish Mohammed, Deborah Turbitt, Clare Cook, Rachel Pitt
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Letter
medicine.medical_treatment
Drug resistance
Azithromycin
medicine.disease_cause
chemistry.chemical_compound
Gonorrhea
0302 clinical medicine
Medicine
030212 general & internal medicine
Ceftriaxone
Anti-Bacterial Agents
Treatment Outcome
whole-genome sequencing
surveillance
Gentamicin
Female
epidemiology
Ertapenem
Rapid Communication
medicine.drug
Adult
030106 microbiology
Sexually Transmitted Diseases
Microbial Sensitivity Tests
Polymorphism
Single Nucleotide
03 medical and health sciences
Antibiotic resistance
Virology
Drug Resistance
Bacterial
Humans
antimicrobial resistance
antimicrobial treatment
sexually transmitted infections
treatment failure
Whole Genome Sequencing
business.industry
Public Health
Environmental and Occupational Health
gonorrhoeae
Neisseria gonorrhoeae
United Kingdom
chemistry
Spain
Beta-lactamase
business
Zdroj: Eyre, D W, Town, K, Street, T, Barker, L, Sanderson, N, Cole, M J, Mohammed, H, Pitt, R, Gobin, M, Irish, C, Gardiner, D, Sedgwick, J, Beck, C, Saunders, J, Turbitt, D, Cook, C, Phin, N, Nathan, B, Horner, P & Fifer, H 2019, ' Detection in the United Kingdom of the Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate resistance to azithromycin, October to December 2018 ', Eurosurveillance, vol. 24, no. 10, 1900147 . https://doi.org/10.2807/1560-7917.ES.2019.24.10.1900147
Eurosurveillance
DOI: 10.2807/1560-7917.ES.2019.24.10.1900147
Popis: We describe detection in the United Kingdom (UK) of the drug-resistant Neisseria gonorrhoeae FC428 clone, with ceftriaxone resistance and intermediate azithromycin resistance. Two female patients developed infection following contact with UK-resident men from the same sexual network linked to travel to Ibiza, Spain. One case failed treatment with ceftriaxone, and azithromycin and gentamicin, before successful treatment with ertapenem. Both isolates had indistinguishable whole-genome sequences. Urgent action is essential to contain this drug-resistant strain.
Databáze: OpenAIRE
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