Antibody response and self-reported adverse reactions following vaccination with Comirnaty: a pilot study from a Croatian university hospital
| Autor: | Dragana Šegulja, Ivana Lapić, Dunja Rogić, Ljiljana Zaninović |
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| Rok vydání: | 2021 |
| Předmět: |
myalgia
medicine.medical_specialty Croatia Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pilot Projects Antibodies Viral Gastroenterology Pathology and Forensic Medicine Internal medicine medicine Humans Aged Croatian biology SARS-CoV-2 business.industry Vaccination COVID-19 General Medicine Hospitals language.human_language Titer Antibody response Antibody Formation biology.protein language Chills Self Report medicine.symptom Antibody business |
| Zdroj: | Journal of Clinical Pathology. 75:782-786 |
| ISSN: | 1472-4146 0021-9746 |
| Popis: | This study aimed to determine antibody responses against SARS-CoV-2 spike (S) after both BioNTech–Pfizer Comirnaty vaccine doses and study the correlation with self-perceived adverse reactions. Antibodies determination with Elecsys anti-SARS-CoV-2 S assay was performed a day prior to or just before administration of the second dose and 8–13 days after the second dose. Participants selected from a predefined list of the experienced local (injection site reactions) and/or systemic (fatigue, headache, myalgia, arthralgia, chills and fever) post-vaccination adverse reactions. An average 100-fold increase in antibody titre in naive vaccinees was observed between the two time points (median 67 U/mL vs 2841 U/mL, p |
| Databáze: | OpenAIRE |
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