Pharmacokinetics in plasma and alveolar regions of a healthy calf intramuscularly administered a single dose of orbifloxacin

Autor:	Tetsuro, Kuramae, Shingo, Ishikawa, Aki, Kono, Seiji, Hobo
Rok vydání:	2022
Předmět:	General Veterinary Ciprofloxacin Alveolar Epithelial Cells Animals Cattle Bronchoalveolar Lavage Fluid Anti-Bacterial Agents
Zdroj:	Journal of Veterinary Medical Science. 84:400-405
ISSN:	1347-7439 0916-7250
Popis:	This study analyzed the pharmacokinetics of orbifloxacin (OBFX) in plasma, and its migration and retention in epithelial lining fluid (ELF) and alveolar cells within the bronchoalveolar lavage fluid (BALF). Four healthy calves received a single dose of OBFX (5.0 mg/kg) intramuscularly. Post-administration OBFX dynamics were in accordance with a non-compartment model, including the absorption phase. The maximum concentration (C
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2293fb91434924975e8534346fa1b2c1 https://doi.org/10.1292/jvms.21-0517 Zobrazit plný text záznamu