Anti-Inflammatory and Anti-Thrombotic Effects of the Fungal Metabolite Galiellalactone in Apolipoprotein E-Deficient Mice
| Autor: | Jackel, Sven, Bollmann, Franziska, Schmidtke, Lisa, Schrick, Katharina, Reinhardt, Christoph, Jurk, Kerstin, Wu, Zhixiong, Xia, Ning, Li, Huige, Erkel, Gerhard, Walter, Ulrich, Kleinert, Hartmut, Pautz, Andrea |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Mice
Knockout Whole Blood Coagulation Time lcsh:R 610 Medizin Anti-Inflammatory Agents lcsh:Medicine Atherosclerosis Mice Inbred C57BL Disease Models Animal Lactones Mice Apolipoproteins E Carotid Arteries Platelet Adhesiveness Fibrinolytic Agents 610 Medical sciences Animals Cytokines lcsh:Q Carotid Artery Thrombosis lcsh:Science Blood Coagulation Research Article |
| Zdroj: | PLoS ONE, Vol 10, Iss 6, p e0130401 (2015) PLoS ONE |
| ISSN: | 1932-6203 |
| Popis: | Patients suffering from chronic inflammatory diseases have an increased mortality risk resulting from cardiovascular disorders due to enhanced atherosclerotic and thrombotic events. Until now, it is not completely understood in which way an abnormal expression of pro-inflammatory mediators contributes to this elevated cardiovascular risk, but there is a need for new drugs that on the one hand suppress the expression of pro-inflammatory mediators and on the other hand inhibit arterial platelet adhesion. Thus, we analyzed the anti-inflammatory and anti-thrombotic capacity of the fungal metabolite Galiellalactone in atherosclerosis-prone apolipoprotein E-deficient mice. Treatment of the mice with Galiellalactone lowered the inflammatory expression profile and improved blood clotting times, as well as platelet adhesion to the injured common carotid artery. The results indicate that administration of Galiellalactone is able to reduce the extent of inflammation and arterial platelet adhesion in this mouse model. |
| Databáze: | OpenAIRE |
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