Status of antithyroid antibodies in Bangladesh
| Autor: | M A Hasanat, Mahjabeen Alam, K Nadim Hasan, M.A.K. Rumi, Mohamed Abdel Salam, Hajera Mahtab, M Fariduddin, Md. Salimullah, A.K.Azad Khan |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Male medicine.medical_specialty endocrine system endocrine system diseases medicine.medical_treatment Gastroenterology Thyroglobulin Thyroiditis Internal medicine Microsomes medicine Prevalence Humans Toxic multinodular goitre Subacute thyroiditis Autoantibodies Analysis of Variance Bangladesh Chi-Square Distribution business.industry Thyroid disease Thyroid Autoantibody Thyroiditis Autoimmune General Medicine Original Articles medicine.disease Thyroid Diseases Anti-thyroid autoantibodies medicine.anatomical_structure Case-Control Studies Immunology Female business Biomarkers |
| Zdroj: | Postgraduate medical journal. 76(896) |
| ISSN: | 0032-5473 |
| Popis: | To study autoimmunity among thyroid diseases, 397 thyroid patients (age 30 (13) years; M/F 75/322) from two referral centres in Bangladesh and 94 healthy controls (age 30 (13) years; M/F 24/70) were studied for antimicrosomal and antithyroglobulin antibodies. Thyroid patients were clinically grouped as suspected autoimmune thyroid disease (AITD), non-autoimmune, or indeterminate groups (where no decision could be reached). Antimicrosomal antibody was strongly positive in 19.4% and weakly positive in 7.3% of patients but only 4.3% and 2.1% respectively in the controls (χ2 = 17.852; p = 0.000) whereas strong and weak positivity were 27.2% and 6.8% in patients compared with 8.5% and 4.3% respectively in the controls (χ2 = 16.916; p = 0.000) for antithyroglobulin antibody. Antibodies were positive in 63.0% with Hashimoto's thyroiditis, 36.4% with Graves' disease, and 44.7% with atrophic thyroiditis among the autoimmune group. In the non-autoimmune group antibodies were positive in 100% with multinodular hypothyroidism, 46.7% with subacute thyroiditis, 40.0% with suspected iodine deficiency goitre, 31.3% with toxic multinodular goitre, 30.8% with non-toxic solitary nodules, and 19.4% with simple diffuse goitre. None was positive for antimicrosomal antibody without being positive for antithyroglobulin antibody. The two antibodies strongly correlated in both patients (r = 0.977, p = 0.000) and controls (r = 0.986, p = 0.000). About 9% (36/397) of patients were mismatched with the final diagnosis on antibody measurement; most of them had Hashimoto's thyroiditis (33/36). Prevalence of AITD among thyroid patients was 48.36%. Specificity of antimicrosomal and antithyroglobulin antibodies were 93% and 87%. It was concluded that AITD is not uncommon in Bangladesh; antimicrosomal antibody is a useful marker for AITD and unless antibodies are checked, an appreciable number of patients with AITDs will remain undetected. |
| Databáze: | OpenAIRE |
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