A 3D glass optrode array for optical neural stimulation
| Autor: | Florian Solzbacher, Loren Rieth, Prashant Tathireddy, T. V. F. Abaya, Steve Blair |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: |
Materials science
Optical fiber Novel Light Sources Optics and Detectors Collimated light law.invention ocis:(170.3660) Light propagation in tissues 03 medical and health sciences ocis:(230.7380) Waveguides channeled 0302 clinical medicine Optics law Transmittance 030304 developmental biology 0303 health sciences Total internal reflection Scattering business.industry Fresnel equations Atomic and Molecular Physics and Optics Optode business ocis:(170.3890) Medical optics instrumentation 030217 neurology & neurosurgery Beam (structure) ocis:(220.4610) Optical fabrication Biotechnology |
| Zdroj: | Biomedical Optics Express |
| ISSN: | 2156-7085 |
| Popis: | This paper presents optical characterization of a first-generation SiO(2) optrode array as a set of penetrating waveguides for both optogenetic and infrared (IR) neural stimulation. Fused silica and quartz discs of 3-mm thickness and 50-mm diameter were micromachined to yield 10 × 10 arrays of up to 2-mm long optrodes at a 400-μm pitch; array size, length and spacing may be varied along with the width and tip angle. Light delivery and loss mechanisms through these glass optrodes were characterized. Light in-coupling techniques include using optical fibers and collimated beams. Losses involve Fresnel reflection, coupling, scattering and total internal reflection in the tips. Transmission efficiency was constant in the visible and near-IR range, with the highest value measured as 71% using a 50-μm multi-mode in-coupling fiber butt-coupled to the backplane of the device. Transmittance and output beam profiles of optrodes with different geometries was investigated. Length and tip angle do not affect the amount of output power, but optrode width and tip angle influence the beam size and divergence independently. Finally, array insertion in tissue was performed to demonstrate its robustness for optical access in deep tissue. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|