Thyroid Hormone Concentrations and Free Thyroxine Status in Neonatal Venous and Capillary Serum Pairs
| Autor: | Collen M O'Grady, R C Franklin |
|---|---|
| Rok vydání: | 1984 |
| Předmět: |
Thyroid Hormones
030213 general clinical medicine medicine.medical_specialty Globulin Clinical Biochemistry 030209 endocrinology & metabolism Veins Thyroxine-Binding Proteins 03 medical and health sciences 0302 clinical medicine Internal medicine Humans Medicine biology business.industry Thyroid Infant Newborn Radioimmunoassay General Medicine Venous blood biology.organism_classification Capillaries Thyroxine Endocrinology medicine.anatomical_structure Tasa biology.protein Sample collection Thyroxine-binding proteins business Hormone |
| Zdroj: | Annals of Clinical Biochemistry: International Journal of Laboratory Medicine. 21:306-309 |
| ISSN: | 1758-1001 0004-5632 |
| DOI: | 10.1177/000456328402100413 |
| Popis: | The levels of thyroid hormones in paired venous and capillary serum samples taken from 68 healthy full-term neonates were determined by radioimmunoassay. Compared with capillary values, total thyroxine (T4), thyrotropin (TSH) and thyroxine-binding globulin (TBG) each showed a significant decrease in venous serum. The mean venous and capillary concentrations of tri-iodothyronine (T3), reverse tri-iodothyronine (rT3) and free thyroxine (fT4) were not significantly different; however, in each case the fitted linear relationship suggested that venous and capillary values were not concordant ( P3 uptake test and the free thyroxine index (FTI) were significantly higher in venous serum, while the ratios of T4 to TBG in paired samples were equivalent. These results suggest that consistent sample collection and assay methods should be applied when assessing neonatal thyroid status, particularly if comparison of results is intended. |
| Databáze: | OpenAIRE |
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