Metabolic responses of Eisenia fetida after sub-lethal exposure to organic contaminants with different toxic modes of action
| Autor: | Jennifer R. McKelvie, Magda A. Celejewski, André J. Simpson, Myrna J. Simpson, Mehran Alaee, David M. Wolfe |
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| Rok vydání: | 2011 |
| Předmět: |
Eisenia fetida
Magnetic Resonance Spectroscopy Health Toxicology and Mutagenesis 010501 environmental sciences Toxicology 01 natural sciences 03 medical and health sciences chemistry.chemical_compound Metabolomics Carbaryl Animals Soil Pollutants Oligochaeta Organic Chemicals 030304 developmental biology 0105 earth and related environmental sciences 0303 health sciences biology General Medicine Pesticide biology.organism_classification Pollution 3. Good health Nonylphenol chemistry Chlorpyrifos Environmental chemistry Toxicity Metabolome Dimethyl phthalate |
| Zdroj: | Environmental pollution (Barking, Essex : 1987). 159(12) |
| ISSN: | 1873-6424 |
| Popis: | Nuclear magnetic resonance (NMR) – based metabolomics has the potential to identify toxic responses of contaminants within a mixture in contaminated soil. This study evaluated the metabolic response of Eisenia fetida after exposure to an array of organic compounds to determine whether contaminant-specific responses could be identified. The compounds investigated in contact tests included: two pesticides (carbaryl and chlorpyrifos), three pharmaceuticals (carbamazephine, estrone and caffeine), two persistent organohalogens (Aroclor 1254 and PBDE 209) and two industrial compounds (nonylphenol and dimethyl phthalate). Control and contaminant-exposed metabolic profiles were distinguished using principal component analysis and potential contaminant-specific biomarkers of exposure were found for several contaminants. These results suggest that NMR-based metabolomics offers considerable promise for differentiating between the different toxic modes of action (MOA) associated with sub-lethal toxicity to earthworms. |
| Databáze: | OpenAIRE |
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