Alkaloid synthesis via [3+2] cycloadditions

Autor:	William H. Pearson
Rok vydání:	2002
Předmět:	Chemistry Stereochemistry General Chemical Engineering Lapidilectine B Lepadiformine Alkaloid synthesis Total synthesis Organic chemistry General Medicine General Chemistry Indolizidine 239CD
Zdroj:	Pure and Applied Chemistry. 74:1339-1347
ISSN:	1365-3075 0033-4545
DOI:	10.1351/pac200274081339
Popis:	Tin-lithium exchange on (2-azaallyl)stannanes affords nonstabilized 2-azaallyllithiums (2-azaallyl anions) that undergo [π4s+π2s] cycloadditions with alkenes to afford pyrrolidines. The scope of this method has been expanded to include 2-azapentadienyllithiums and heteroatom-substituted 2-azaallyllithiums. Alternatively, the (2-azaallyl)stannanes may also be used to generate nonstabilized azomethine ylides via N-alkylation/destannylation or N-protonation/destannylation, and these ylides were also found to be useful for the synthesis of pyrrolidines by [π4s+π2s] cycloadditions with alkenes. Applications of both methods to the total synthesis of alkaloids such as (+)-coccinine, lepadiformine stereoisomers, lapidilectine B, and indolizidine 239CD have been accomplished.
Databáze:	OpenAIRE
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