Performance of HPV16/18 in Triage of Cytological Atypical Squamous Cells of Undetermined Significance
Autor: | Ling-Yan Ren, Xiaoqin Cao, Zhen Guo, Xibin Sun, Bing Dong, Hongmin Chen, Dong-Mei Zhao, Shaokai Zhang, Shuzheng Liu, Man-Man Jia |
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Rok vydání: | 2019 |
Předmět: |
Adult
Cancer Research medicine.medical_specialty China Article Subject Cytodiagnosis Uterine Cervical Neoplasms Context (language use) Atypical Squamous Cells Sensitivity and Specificity Pathology and Forensic Medicine 03 medical and health sciences 0302 clinical medicine Risk Factors Cytology Internal medicine medicine Atypical Squamous Cells of the Cervix Prevalence Humans 030212 general & internal medicine Trial registration RC254-282 Early Detection of Cancer Colposcopy Human papillomavirus 16 medicine.diagnostic_test QH573-671 Human papillomavirus 18 business.industry Papillomavirus Infections Clinical performance Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Cell Biology General Medicine Middle Aged medicine.disease Uterine Cervical Dysplasia Triage female genital diseases and pregnancy complications 030220 oncology & carcinogenesis Molecular Medicine Female business Research Article |
Zdroj: | Analytical Cellular Pathology (Amsterdam) Analytical Cellular Pathology, Vol 2019 (2019) |
ISSN: | 2210-7185 |
Popis: | Context. Human papillomavirus (HPV) testing is widely used in cervical cancer screening in women; however, its efficiency in triaging women with atypical squamous cells of undetermined significance (ASC-US) needs to be validated. Objective. To evaluate the performance of HPV16/18 in the triage of women with ASC-US. Methods. Women presenting for routine cervical cancer screening had cervical specimens collected, with which both liquid-based cytology (LBC) and hrHPVs were examined; those with ASC-US cytology underwent colposcopy. HPV16/18 and 12 other types were tested with domestic hybridization capture and chemiluminescence signal amplification (DH3). Performance characteristics of HPV test (sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) for identification of cervical intraepithelium neoplasma (CIN) grade 2 or worse (CIN2+), and CIN grade 3 or worse (CIN3+)) were determined using standard statistical tests. Results. 317 women with ASC-US were eligible for the study. HrHPV prevalence was 15.77% (50/317); HPV16/18 prevalence was 3.61% (20/317). Sensitivity and specificity of HPV16/18 for detection of CIN 2+ were 64.71% and 97% and 64.29% and 96.37% for detection of CIN 3+, respectively. The positive predictive values (PPVs) and negative predictive values (NPVs) of HPV16/18 were 55.00% and 97.98% for CIN2+ and 45.00% and 98.32% for CIN3+, respectively. Conclusion. HPV16/18 can be considered as an effective method to triage women with ASC-US as its good clinical performance. Trial Registration. This trial is registered with Henan Cancer Hospital Medical Ethics Committee on July 5, 2016 (http://www.anti-cancer.com.cn), with registry no.: 2016037. |
Databáze: | OpenAIRE |
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