Performance of HPV16/18 in Triage of Cytological Atypical Squamous Cells of Undetermined Significance

Autor: Ling-Yan Ren, Xiaoqin Cao, Zhen Guo, Xibin Sun, Bing Dong, Hongmin Chen, Dong-Mei Zhao, Shaokai Zhang, Shuzheng Liu, Man-Man Jia
Rok vydání: 2019
Předmět:
Adult
Cancer Research
medicine.medical_specialty
China
Article Subject
Cytodiagnosis
Uterine Cervical Neoplasms
Context (language use)
Atypical Squamous Cells
Sensitivity and Specificity
Pathology and Forensic Medicine
03 medical and health sciences
0302 clinical medicine
Risk Factors
Cytology
Internal medicine
medicine
Atypical Squamous Cells of the Cervix
Prevalence
Humans
030212 general & internal medicine
Trial registration
RC254-282
Early Detection of Cancer
Colposcopy
Human papillomavirus 16
medicine.diagnostic_test
QH573-671
Human papillomavirus 18
business.industry
Papillomavirus Infections
Clinical performance
Cancer
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Cell Biology
General Medicine
Middle Aged
medicine.disease
Uterine Cervical Dysplasia
Triage
female genital diseases and pregnancy complications
030220 oncology & carcinogenesis
Molecular Medicine
Female
business
Research Article
Zdroj: Analytical Cellular Pathology (Amsterdam)
Analytical Cellular Pathology, Vol 2019 (2019)
ISSN: 2210-7185
Popis: Context. Human papillomavirus (HPV) testing is widely used in cervical cancer screening in women; however, its efficiency in triaging women with atypical squamous cells of undetermined significance (ASC-US) needs to be validated. Objective. To evaluate the performance of HPV16/18 in the triage of women with ASC-US. Methods. Women presenting for routine cervical cancer screening had cervical specimens collected, with which both liquid-based cytology (LBC) and hrHPVs were examined; those with ASC-US cytology underwent colposcopy. HPV16/18 and 12 other types were tested with domestic hybridization capture and chemiluminescence signal amplification (DH3). Performance characteristics of HPV test (sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) for identification of cervical intraepithelium neoplasma (CIN) grade 2 or worse (CIN2+), and CIN grade 3 or worse (CIN3+)) were determined using standard statistical tests. Results. 317 women with ASC-US were eligible for the study. HrHPV prevalence was 15.77% (50/317); HPV16/18 prevalence was 3.61% (20/317). Sensitivity and specificity of HPV16/18 for detection of CIN 2+ were 64.71% and 97% and 64.29% and 96.37% for detection of CIN 3+, respectively. The positive predictive values (PPVs) and negative predictive values (NPVs) of HPV16/18 were 55.00% and 97.98% for CIN2+ and 45.00% and 98.32% for CIN3+, respectively. Conclusion. HPV16/18 can be considered as an effective method to triage women with ASC-US as its good clinical performance. Trial Registration. This trial is registered with Henan Cancer Hospital Medical Ethics Committee on July 5, 2016 (http://www.anti-cancer.com.cn), with registry no.: 2016037.
Databáze: OpenAIRE
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