Automated Light- and Dark-Adapted Perimetry for Evaluating Retinitis Pigmentosa: Filling a Need to Accommodate Multicenter Clinical Trials
| Autor: | Michaela L. Gruzensky, Rebecca Sheplock, Rodrigo Matsui, David B. McGuigan, Samuel G. Jacobson, Alejandro J. Roman, Artur V. Cideciyan |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty genetic structures Dark Adaptation Perimeter Young Adult 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Ophthalmology Sensory threshold Retinitis pigmentosa medicine Humans Multicenter Studies as Topic Chromatic scale Aged Decibel Clinical Trials as Topic Adaptation Ocular business.industry Reproducibility of Results Retinal Middle Aged medicine.disease Visual field Dark-adapted 030104 developmental biology chemistry Sensory Thresholds 030221 ophthalmology & optometry Visual Field Tests Female sense organs business Photic Stimulation Retinitis Pigmentosa Photoreceptor Cells Vertebrate |
| Zdroj: | Investigative Opthalmology & Visual Science. 57:3118 |
| ISSN: | 1552-5783 |
| DOI: | 10.1167/iovs.16-19302 |
| Popis: | Purpose The purpose of this study was to develop a convenient means to measure rod (and cone) function by automated perimetry in patients with inherited retinal degenerations (IRDs). Methods A currently available automated perimeter was used to determine sensitivity (in decibels) to a blue target in the dark-adapted (DA) state and a white target in the light-adapted (LA) state. Normal subjects and IRD patients were evaluated with a full-threshold 71-locus strategy (the retinitis pigmentosa [RP] test) and a size III target. Comparisons were made with results from the more commonly used methods of two-color DA perimetry and middle/long-wavelength LA perimetry in the same patients. Results Rod function using the blue target and the RP test was determined for normal subjects by measuring DA sensitivities. If patients detected the blue stimulus in the DA state, it was determined whether the value was rod mediated by using normal data acquired during the cone plateau phase of dark adaptation. If rod mediated, rod sensitivity loss (RSL) was calculated and mapped across the visual field. Light-adapted sensitivities in normal subjects were also measured, permitting cone sensitivity losses (CSL) to be calculated for the patients. Multiple methods were used to compare RSL and CSL results with those from two-color DA perimetry and chromatic LA perimetry, and there was close correspondence between the methods. Conclusions The unmodified automated static perimeter used in the DA and LA states presents a practical approach to accomplish current goals of treatment trials in IRDs. This proof-of-principle study is an initial step toward establishing a clinical method to gather reproducible data on photoreceptor-mediated sensitivity. |
| Databáze: | OpenAIRE |
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